Efficacy of concurrent chemoradiotherapy with S‐1 vs. radiotherapy alone for elderly patients with esophageal cancer: a meta‐analysis
Yang Jianquan1,2, Guo Wen3, Lang Jinyi1,4, Lu Man1,2
1School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China; 2Department of Ultrasound, Sichuan Cancer Hospital, University of Electronic Science and Technology of China, Chengdu 610041, China; 3School of Pharmacy, North Sichuan Medical University, Nanchong 637000, China; 4Department of Radiotherapy, Sichuan Cancer Hospital, University of Electronic Science and Technology of China, Chengdu 610041, China
Abstract：Objective To evaluate the efficacy of concurrent radiotherapy combined with S‐1 (CCRT) versus radiotherapy (RT) alone in elderly patients with esophageal cancer by Meta‐analysis. Methods The Cochrane Library, PubMed, Web of science, EMbase, CBM, CNKI, VIP and Wanfang database were searched. The eligible studies were subject to evaluation of methodological quality. The Meta‐analysis was performed by the Revman 5.3 software. Results A total of 1693 patients were enrolled in 23 studies. The results showed that CCRT increased the incidence of CR [OR=2.08,95%CI (1.66‐2.61), P<0.001] and PR [OR=1.31,95%CI (1.08‐1.60), P=0.007] and total response rate [OR=2.99,95%CI (2.37‐3.77), P<0.001]. Furthermore, CCRT improved the 1‐year survival rate [OR=2.56, 95%CI (1.94‐3.38), P<0.001] and 2‐year survival rate [OR=2.33, 95%CI (1.77‐3.08), P<0.001]. Meanwhile, CCRT reduced the incidence of leucopenia, thrombocytopenia, radioactive esophagitis, nausea and vomiting (all P<0.05), but there was no significant difference in the incidence of anemia and radiation pneumonia between two groups (both P>0.05). Conclusions Available evidence suggests that CCRT combined with S‐1 can improve therapeutic efficacy and prolong survival time in elderly patients with esophageal cancer, but CCRT may increase the incidence of treatment‐related side effects. Due to the limitations of the number and quality of the included studies, the above conclusions need to be verified by more high‐quality studies.
Yang Jianquan,Guo Wen,Lang Jinyi et al. Efficacy of concurrent chemoradiotherapy with S‐1 vs. radiotherapy alone for elderly patients with esophageal cancer: a meta‐analysis[J]. Chinese Journal of Radiation Oncology, 2022, 31(9): 791-797.
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