Research progress on the role of astrocytes in radiation-induced brain injury
Zhu Wenjun1, Peng Xiaohong1, Li Xiaoyu1, Luo Na1, Tang Wenhua2, Fu Min1, Zhang Yuanyuan1, Yang Feng1, Zhou Haiting1, Wen Su1
1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2Department of Oncology, Chengdu Seventh People's Hospital, Chengdu 610000, China
Abstract：Radiation-induced brain injury (RBI) is one of the complications after radiotherapy for head and neck malignant tumors, which seriously affects the quality of life of patients. The pathophysiological mechanism of RBI is not completely clear. Current studies suggest that it is involved in a variety of cells in the central nervous system (CNS), whereas astrocyte, as the largest number of glial cells in the CNS, plays an important role in maintaining the CNS homeostasis and responding to CNS injury. In this article, the role of astrocytes in RBI was reviewed.
Zhu Wenjun,Peng Xiaohong,Li Xiaoyu et al. Research progress on the role of astrocytes in radiation-induced brain injury[J]. Chinese Journal of Radiation Oncology, 2022, 31(6): 589-593.
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