早期非小细胞肺癌立体定向放疗计划自动评估研究与实现

doi:10.3760/cma.j.cn113030-20210605-00216

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摘要目的在Eclipse计划系统中实现早期非小细胞肺癌(NSCLC)体部立体定向放疗计划中靶区适形度、剂量溢出、剂量跌落等指标的自动评估。方法使用Eclipse Scripting API应用程序开发接口和C#编程语言,以脚本插件结合可执行程序的方式进行开发。根据美国肿瘤放射治疗协作组(RTOG)0915号报告中NSCLC立体定向放疗计划要求,实现相关指标的自动评估,其中还设计了一种等间距采样和双阈值的规则,可以更精确和便捷进行靶区外剂量跌落的评估。结果随机选取临床上 13例NSCLC立体定向放疗计划,分别使用本文中的方法和Eclipse系统自带的模块进行评估结果对比可知,两种方式评估结果都符合临床要求,耗时分别为(6.31±1.11) s和(678.54±60.92) s,使用前者评估效率更高(P<0.05)。结论 NSCLC立体定向放疗计划评估软件界面友好,能实现靶区适形度、剂量溢出和剂量跌落等指标的自动评估,有效的提高了工作效率。

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	黄仕雄
	杨松华
	曾德高
	曾彪

关键词 ： Eclipse 脚本, 剂量跌落, 自动评估, 癌,非小细胞肺/体部立体定向放射疗法

Abstract：Objective To realize the automatic evaluation of the target conformity, dose overflow, dose drop and other indicators in stereotactic body radiation therapy (SBRT) plan for the early non-small cell lung cancer (NSCLC) in the Eclipse planning system. Methods Eclipse Scripting API application development interface and C# programming language were used to develop it with script plug-ins combined with independent programs. According to the requirements of the NSCLC SBRT plan in Radiation Therapy Oncology Group (RTOG) 0915 report, the automatic evaluation of related indicators was realized. A rule of equal interval sampling and double thresholds was designed during the period,which could more accurately and conveniently evaluate the dose drop outside the target area. Results 13 clinical cases of NSCLC SBRT plans were randomly selected, the method in this study and the module equipped with the Eclipse system to were utilized to evaluate and compare the results. It was concluded that the results of the two methods were in line with the clinical requirements, and the former was more efficient (P<0.05). Conclusions The NSCLC SBRT plan evaluation software in this article has a friendly interface. It can not only realize the automatic evaluation of target conformity, dose overflow and dose drop, but also effectively improve work efficiency and better serve the clinical and scientific research work of radiotherapy.

Key words： Eclipse scripting Dose drop Automatic evaluation Carcinoma, non-small cell lung/stereotactic body radiation therapy

收稿日期: 2021-06-05

基金资助:长沙市科技局基础研究项目(KP2004140);湖南省自然科学基金科卫联合基金项目(2018JJ6090);国家癌症中心肿瘤科研专项课题(NCC2017A18)

通讯作者: 曾彪,Email:zengbiao008@163.com

引用本文:

黄仕雄,杨松华,曾德高等. 早期非小细胞肺癌立体定向放疗计划自动评估研究与实现[J]. 中华放射肿瘤学杂志, 2022, 31(4): 352-358.

Huang Shixiong,Yang Songhua,Zeng Degao et al. Research and realization of automatic evaluation of stereotactic radiotherapy plan for early non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(4): 352-358.

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