Advances in organ preservation for locally advanced rectal cancer after neoadjuvant chemoradiotherapy
Zhao Ying, Tang Yuan, Jin Jing
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Abstract：Neoadjuvant chemoradiotherapy combined with total mesorectal excision is the standard treatment for stage T3-T4/N+ locally advanced rectal cancer (LARC). However, proctectomy is burdened with consistent postoperative morbidity, severely affecting the quality of life. “Organ preserving” methods could achieve similar oncological outcomes in highly selected patients whose tumors demonstrate (almost) clinical complete response to neoadjuvant treatment, while maintaining the quality of life and anorectal function by keeping the anus. This article aims to summarize the strategies of organ preservation after neoadjuvant treatment of LARC, salvage treatment for regrowth or recurrence, and anorectal function after organ preservation strategies.
Zhao Ying,Tang Yuan,Jin Jing. Advances in organ preservation for locally advanced rectal cancer after neoadjuvant chemoradiotherapy[J]. Chinese Journal of Radiation Oncology, 2022, 31(2): 208-213.
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