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残余淋巴结短径与食管鳞癌放化疗疗效和预后相关性及Nomogram模型建立
马媛媛, 夏建洪, 李宏亮, 苏欣宇, 周立庆
徐州医科大学附属淮安医院,淮安市第二人民医院放射肿瘤科 223000
Correlation of short diameter of residual lymph nodes with efficacy and prognosis in esophageal squamous cell carcinoma patients undergoing chemoradiotherapy and establishment of a Nomogram model
Ma Yuanyuan, Xia Jianhong, Li Hongliang, Su Xinyu, Zhou Liqing
Department of Radiation Oncology, Affiliated Huai'an Hospital of Xuzhou Medical University, Second People's Hospital of Huai'an, Huai'an 223000, China
Abstract：Objective To analyze the correlation of the short diameter of residual lymph nodes with the efficacy and prognosis of patients with esophageal squamous cell carcinoma (ESCC) undergoing chemoradiotherapy (CRT), and establish a Nomogram prediction model to predict the prognosis of ESCC patients. Methods Clinical data of 143 ESCC patients who underwent CRT in Second People's Hospital of Huai'an from August 2018 to September 2020 were collected. The survival analysis was conducted with Kaplan-Meier method, log-rank test and univariate prognostic analysis. Multivariate prognostic analysis was performed with Cox models. Finally, a Nomogram prediction model was established to predict the 1-year and 2-year progression-free survival (PFS) of patients, and the C-index, AUC, and calibration curve were used to evaluate the performance of the model. Results Logistic regression analysis results showed that differentiation, TNM staging, PG-SGA scores before and after radiotherapy (RT) and short diameter of residual lymph nodes were the independent predictors of clinical efficacy of ESCC patients treated with CRT. Cox regression analysis demonstrated that differentiation, TNM staging, PG-SGA scores before and after RT and short diameter of residual lymph nodes were the independent prognostic predictors of ESCC patients undergoing CRT. Conclusions The short diameter of residual lymph nodes is significantly correlated with the efficacy and prognosis of ESCC patients undergoing CRT. The Nomogram prediction model established after comprehensive clinical baseline characteristics is a practical and reliable tool for predicting clinical prognosis of ESCC patients.
Ma Yuanyuan,Xia Jianhong,Li Hongliang et al. Correlation of short diameter of residual lymph nodes with efficacy and prognosis in esophageal squamous cell carcinoma patients undergoing chemoradiotherapy and establishment of a Nomogram model[J]. Chinese Journal of Radiation Oncology, 2021, 30(12): 1244-1249.
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2021, Vol. 30 
