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SPECT肺灌注显像优化肺癌放疗计划对肺功能保护价值的研究
刘霁1, 郝美丽2, 谭叶1, 江晓虹1, 陆海军1
1青岛大学附属医院肿瘤放疗科 266000; 2潍坊医学院附属医院放疗科 261000
Study of the value of SPECT lung perfusion imaging in optimizing lung cancer radiotherapy plan for lung function protection
Liu Ji1, Hao Meili2, Tan Ye1, Jiang Xiaohong1, Lu Haijun1
1Department of Oncology, Affiliated Hospital of Qingdao University, Qingdao 266000, China; 2Department of Radiotherapy, Affiliated Hospital of Weifang Medical University, Weifang 261000, China
Abstract：Objective To evaluate the application value of SPECT lung perfusion imaging in guiding radiotherapy path, optimizing the radiotherapy plan for lung cancer and protecting lung function during radiotherapy for locally advanced non-small cell lung cancer. Methods In this study, 84 patients with stage Ⅲ non-resectable non-small cell lung cancer were randomly divided into the control group (n=44) and observation group (n=40). In the control group, radiotherapy plan based on conventional CT images was delivered, and two plans based on the lung function information suggested by conventional CT and SPECT lung perfusion imaging:P1 and P2 were given in the observation group. All patients in the observation group were finally treated according to the P2 plan. The incidence of radiation pneumonitis, and changes in lung function before and after radiotherapy were statistically compared between two groups. The dose-volume parameters of P1 and P2 were statistically compared. Results After the plan was optimized, the incidence of radiation pneumonitis in the observation group was significantly reduced and the decline of lung function was significantly improved (bothP≤0.001). The functional dose parameters were significantly improved in the P2 plans (bothP<0.05), whereas the irradiation dose of organs at risk did not significantly change (P>0.05). Conclusion SPECT lung perfusion imaging optimizes the intensity-modulated radiotherapy plan, which can reduce the functional lung dose and increase the tumor radiotherapy dose without increasing the irradiation dose of other organs at risk.
Liu Ji,Hao Meili,Tan Ye et al. Study of the value of SPECT lung perfusion imaging in optimizing lung cancer radiotherapy plan for lung function protection[J]. Chinese Journal of Radiation Oncology, 2021, 30(11): 1117-1121.
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2021, Vol. 30 
