Clinical efficacy of hypofractionated radiotherapy for patients with locally advanced or advanced non-small cell lung cancer
Zhang Jiajia, Cao Yipeng, Chen Siying, Wang Jun, Zhao Lujun, Wang Ping, Liu Ningbo
Department of Radiation Oncology, Cancer Hospital of Tianjin Medical University, National Cancer Clinical Medical Research Center, Tianjin "Tumor Prevention and Control" Key Laboratory, Tianjin Malignant Tumor Clinical Medicine Research Center, Tianjin 300060, China
Abstract：Objective To evaluate the survival outcome and toxicity of hypofractionated radiotherapy (45Gy/15f) in patients with locally advanced/advanced non-small cell lung cancer (NSCLC) who are ineligible for conventional fractionated radiotherapy. Methods The early efficacy, survival and toxicity of inoperable patients (n=64) with locally advanced/advanced NSCLC patients admitted to Cancer Hospital of Tianjin Medical University from 2014 to 2018 were retrospectively analyzed. Hypofractionated radiotherapy (45Gy/15f) were performed by using intensity-modulated radiotherapy or volumetric-modulated arc therapy technologies on Pinnacle 9 planning system. Results The median follow-up time was 26 months. The early efficacy was available in 58 patients:complete response for 2 cases (3%), partial response for 22(38%), stable disease for 28(44%) and progressive disease for 6(9%), respectively. The local control rate was 90%. The median time to progression (TTP) and the median overall survival (OS) for all patients was 8.2 months and 21.0 months, respectively. The 1-, 2-and 3-year TTP rate was 37%, 28%, 14% and the OS rate was 66%, 43% and 27%, respectively. The incidence of esophagitis was 17%(n=11), 19%(n=12) for radiation pneumonitis and 20%(n=13) for myelosuppression. No grade ≥3 esophagitis or pneumonia was found. Conclusion Hypofractionated radiotherapy (45Gy/15f) is efficacious and safe for patients with locally advanced/advanced NSCLC, which yields controllable adverse events.
Zhang Jiajia,Cao Yipeng,Chen Siying et al. Clinical efficacy of hypofractionated radiotherapy for patients with locally advanced or advanced non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(10): 1002-1006.
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