Basic research progress on the combination of heavy ion beam and immunotherapy in the treatment of malignant neoplasm
Geng Yichao1,2, Zhang Qiuning2,3, Lu Bing1, Wang Xiaohu2,3
1Department of Oncology, Affiliated Hospital of Guizhou Medical University, and Guizhou Cancer Hospital, Guiyang 550004, China; 2Department of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 3Lanzhou Heavy Ion Hospital, Lanzhou 730000, China
Abstract：In recent years,heavy ion beams have received great attention in the field of malignant tumor radiotherapy due to their radiation physics and biological characteristics. The high rate of local tumor control is one of its advantages, but the control rate of metastatic lesions is still crucial in the treatment of most malignant tumors. Clinical studies on the combined conventional radiotherapy and immunotherapy suggest that the combination of the two can not only control the primary lesions, but may also reduce or completely eliminate distant metastatic lesions. High linear energy transfer radiation, especially heavy ion beams, may have stronger potential in combined immunotherapy. Therefore, this article focuses on the basic research progress of heavy ion beams regulating anti-tumor immune effects and their combined application with immunotherapy.
Geng Yichao,Zhang Qiuning,Lu Bing et al. Basic research progress on the combination of heavy ion beam and immunotherapy in the treatment of malignant neoplasm[J]. Chinese Journal of Radiation Oncology, 2021, 30(8): 867-870.
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