Kidney motion in each direction and influencing factors derived from four dimensional computed tomography under free-breathing condition
Ma Mingwei1, Gao Xianshu1, Li Hongzhen1, Zhao Bo2,3, Zhang Min1, Liu Siwei1, Qin Shangbin1, Qi Xin1, Bai Yun1
1Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China; 2Department of Engineering Physics, Tsinghua University, Beijing 100084, China; 3Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Tsinghua University, Beijing 100084, China
Abstract：Objective To explore the amplitude of normal kidney motion in the 3D direction and its influencing factors under free-breathing condition. Methods Clinical data of 28 patients with a KPS score≥80 who received 4D CT scan from March 2018 to March 2019 were collected. All patients were diagnosed with liver, pancreatic or lung tumors. The kidney was outlined and the geometric center and 3D coordinate values were recorded. The motion of bilateral kidneys in each direction and the 3D direction was calculated. The volume of kidney and surrounding organs, age, sex, height and body mass index (BMI) were recorded. Clinical data were statistically compared by t-test or nonparametric test. Results The motion of the left and right kidneys in the the sup-inf (SI) direction were the largest up to (8.39±3.18) mm and (7.71±3.55) mm. The motion amplitudes of bilateral kidneys in male patients were significantly larger than those of the female counterparts in the left-right (LR), SI and 3D directions (all P<0.05). The motion amplitudes of bilateral kidneys in patients taller than 165cm were significantly larger than those of their counterparts with a height of ≤165cm (all P<0.05). Patients with a BMI≥25kg/m2had significantly larger motion amplitudes of the left kidney in the LR and ant-post (AP) directions compared with those of normal weight counterparts (all P<0.05). The motion amplitude of the left kidney in the AP direction in patients with the left kidney volume of >180cm3 was significantly larger than that of patients with smaller left kidney volume (P=0.014). Age was not significantly associated with kidney motion in each direction (P>0.05). Conclusions Kidney motion mainly occurs in the SI direction. The kidney motion amplitudes in male and taller patients are larger. Special attention should be paid to the use of breath motion control device to decrease the normal tissue damage.
Ma Mingwei,Gao Xianshu,Li Hongzhen et al. Kidney motion in each direction and influencing factors derived from four dimensional computed tomography under free-breathing condition[J]. Chinese Journal of Radiation Oncology, 2021, 30(5): 481-485.
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2021, Vol. 30 
