Preliminary study of neoadjuvant plus chemotherapy combined with concurrent chemoradiotherapy for locally advanced giant cervical cancer
Yang Hua1, Wei Lichun1, Zhang Ying1, Zhang Jianjun2, Yin Yutian1, Zhou Yan1, Shi Mei1
1Department of Radiation Oncology, First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China; 2Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China
Abstract：Objective To preliminarily investigate the efficacy and safety of bevacizumab plus neoadjuvant chemotherapy combined with concurrent chemoradiotherapy in the treatment of locally advanced giant cervical cancer (LACC). Methods Twenty-four patients with LACC who were treated with bevacizumab combined with neoadjuvant chemotherapy were assigned into the study group, and 30 patients receiving neoadjuvant chemotherapy in phase Ⅱ clinical trial (ChiCTR-TRC-11001832) were allocated in the control group. The survival rate was calculated by the Kaplan-Meier method, and the significance of differences between the variables was determined by the log-rank test. Results The tumor volumes were (1.64±23.15) cm3 and (12.83±15.08)(P=0.037), and the complete remission (CR) rates were calculated as 45.8% and 13.3%(P=0.004) in the study and control groups after neoadjuvant chemotherapy. The tumor volumes were (0±1.5) cm3 and (1.00±10.63) cm3(P=0.022) and the CR rates were 70% and 50%(P=0.009) in the study and control groups before afterloading treatment. The median follow-up was 24.6(9.3-101.7) months. The 1-and 2-year overall survival rates were 96%,96% and 90%,71%(P=0.110),the recurrence-free survival rates was 96%,96% and 97%,89%(P=0.512),and the distant metastasis-free survival rates were 96%, 88% and 83%,80%(P=0.297) in the study and control groups, respectively. Adverse reactions were acceptable in both groups. Conclusion Bevacizumab combined with neoadjuvant chemotherapy can significantly reduce the tumor volume, improve the tumor CR rate and yield tolerable adverse reactions.
Yang Hua,Wei Lichun,Zhang Ying et al. Preliminary study of neoadjuvant plus chemotherapy combined with concurrent chemoradiotherapy for locally advanced giant cervical cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(4): 372-375.
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