Preliminary observation of clinical efficacy of microwave hyperthermia combined with radiochemotherapy for locally advanced gastric cancer
Qi Qing1, Lu Yongchang2, Huo Zhongchao1, Wang Li1, Su Ying1, He Xiaolei1, Li Zhijia1, Wang Wenling1, Lyu Linlin1, Zhou Yongle1, Xu Fei1, Zhao Liwei1
1Department of Radiation Oncology, The Affiliated Hospital of Hebei Engineering University, Handan 056002, China; 2Handan First Hospital, Handan 056002, China
Abstract：Objective To preliminarily observe the clinical efficacy of microwave hyperthermia combined with intensity-modulated radiotherapy (IMRT) and chemotherapy for patients with locally advanced gastric cancer. Methods Forty patients who could not been operated or refused operation were enrolled in this clinical trial, who were confirmed as locally advanced proximal or distal gastric cancer by gastroscopy pathology and imaging. Radiotherapy was delivered by IMRT technology for 5 times per week with a total dose of 46 to 56Gy (median dose of 50Gy) in 25 to 28 fractions. Synchronous hyperthermia was given at 42 to 44℃ twice a week, 45 min/time. S-1 or capecitabine-based synchronous chemotherapy was performed, d1-14/3 weeks. The symptom remission rate, adverse reactions, objective remission rate (complete and partial remission) and survival were observed. Results A total of 40 patients, aged between 56 and 83 years (median age of 71 years), were enrolled in this study. The male-to-female ratio was 7:1. Among them, 38 cases (95%) showed symptom remission. The most common adverse reactions were grade 1-2 gastrointestinal reactions and leukopenia. The objective remission rate was 87.5%, the 2-year progression-free survival and overall survival rates were 68.6% and 70.5%, respectively. Conclusion Preliminary findings demonstrate that microwave hyperthermia combined with chemoradiotherapy achieve satisfactory outcomes and yield tolerable toxicity in patients with locally advanced gastric cancer.
Qi Qing,Lu Yongchang,Huo Zhongchao et al. Preliminary observation of clinical efficacy of microwave hyperthermia combined with radiochemotherapy for locally advanced gastric cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(4): 368-371.
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