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维吾尔族妇女局部晚期宫颈鳞癌外周血T细胞亚群与临床特征和预后关系
郭玉萍, 古丽娜·库尔班, 王若峥
新疆医科大学附属肿瘤医院放疗科,乌鲁木齐 830011
Relationship between T cell subsets in peripheral blood and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma
Guo Yuping, Gulina·Kulban, Wang Ruozheng
Department of Radiotherapy, Cancer Hospital Affiliated to Xinjiang Medical University, Wulumuqi 830011, China
Abstract：Objective To observe the relationship between peripheral blood T cell subsets and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma in Xinjiang. Methods A total of 185 patients pathologically diagnosed with stage ⅡB-IVA cervical squamous cell carcinoma admitted to Cancer Hospital Affiliated to Xinjiang Medical University from January 2015 to December 2018 were selected. The relationship between T cell subsets in peripheral venous blood and clinical characteristics and prognosis was analyzed. Results CD+4 T cells, CD+8 T cells and CD+4/CD+8 T cell ratio were significantly correlated with clinical stage, tumor diameter and body mass index (BMI)(all P<0.05). The later Federation International Association of Gynecology and Obstetrics (FIGO) tumor stage, the larger the tumor diameter, the higher the BMI, and the higher the CD+8 T cells and the lower the CD+4 T cell and CD+4/CD+8 T cell ratio. The count of CD+4 T cells was decreased in patients with lymph node metastasis. Cox’s univariate analysis showed that FIGO stage, age, lymph node metastasis, tumor diameter, BMI, CD+4 T cells, CD+8 T cells, CD+4/CD+8 T cell ratio and treatment methods were the important factors affecting the overall survival (OS). Multivariate analysis showed that BMI, treatment method, CD+4T cells and tumor diameter were the independent prognostic factors affecting OS (all P<0.05). Conclusions The level of T cell subsets in peripheral blood of Uygur cervical cancer patients is out of balance. CD+4T cells, CD+8 T cells and CD+4/CD+8 T cell ratio are associated with FIGO stage, tumor diameter and BMI, and CD+4T cells are correlated with lymph node metastasis. BMI, treatment method, tumor diameter and CD+4 T cell are the independent prognostic factors affecting the OS of patients with cervical cancer.
Guo Yuping,Gulina·Kulban,Wang Ruozheng. Relationship between T cell subsets in peripheral blood and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2020, 29(12): 1064-1069.
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