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109例早期非小细胞肺癌SABR预后分析
郑晓丽, 刘美玲, 王晓辉, 孙亚楠, 宋帅, 杨洋, 焦瑞迪, 叶柯, 范诚诚, 葛红
郑州大学附属肿瘤医院 河南省肿瘤医院放疗科 450008
Analysis of clinical outcomes and prognostic factors in 109 patients with early-stage non-small cell lung cancer treated with stereotactic ablation radiotherapy
Zheng Xiaoli, Liu Meiling, Wang Xiaohui, Sun Yanan, Song Shuai, Yang Yang, Jiao Ruidi, Ye Ke, Fan Chengcheng, Ge Hong
Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China
Abstract：Objective To evaluate the long-term survival and identify prognostic factors of patients diagnosed with early-stage non-small cell lung cancer (ES-NSCLC) receiving stereotactic ablation radiotherapy (SABR). Methods Clinical data of 109 ES-NSCLC patients treated with SABR in Henan Cancer Hospital from 2011 to 2018 were retrospectively analyzed. The overall survival (OS), cancer-specific survival (CSS) and progression-free survival (PFS) were calculated by Kaplan-Meier method and log-rank test. Multivariate prognostic analysis was performed by Cox regression model. Results The median follow-up time was 44 months (2-93 months). The median OS, CSS and PFS were 78 months, 78 months and 44 months, respectively. The 1-year OS, CSS and PFS were 95.4%, 97.2% and 84.1%, and 75.6%, 79.1% and 56.6% for the 3-year OS, CSS and PFS, and 55.6%, 60.7% and 37.3% for the 5-year OS, CSS and PFS, respectively. Univariate analysis showed that ECOG score, age, smoking history and derived-neutrophil/lymphocyte ratio (dNLR) were the influencing factors of OS (P=0.03, 0.02, 0.04, 0.001). Age, smoking history and dNLR were the influencing factors of CSS (P=0.02, 0.03, 0.001). Multivariate analysis demonstrated that dNLR was an independent prognostic factor for OS and CSS (P=0.001, 0.001). Conclusions ES-NSCLC patients treated with SABR can achieve favorable survival. The dNLR is an independent prognostic factor of OS and CSS, which can be considered in clinical application.
Zheng Xiaoli,Liu Meiling,Wang Xiaohui et al. Analysis of clinical outcomes and prognostic factors in 109 patients with early-stage non-small cell lung cancer treated with stereotactic ablation radiotherapy[J]. Chinese Journal of Radiation Oncology, 2020, 29(12): 1031-1036.
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2020, Vol. 29 
