A theoretical investigation on improving the treatment efficiency based on timing characteristics for a proton-and-carbon ion treatment facility
Zhao Jun1,2, Li Yongqiang2, Wu Xianwei2, Xing Ying2
1Department of Radiation Oncology, Fudan University Shanghai Cancer Center,Department of Oncology, Shanghai Medical College,Fudan University,shanghai 200032, China; 2Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai 200120, China
Abstract:Objective To identify the key factors affecting the time of proton and carbon ion radiotherapy by analyzing the timing characteristics of the accelerator system and to find out potential solutions to enhance treatment efficiency. Methods The log files for 47 patients with different types of tumors treated with proton beams and carbon ion beams were analyzed. Lung cancer patients were treated with the gating technology.The timing characteristics of beam delivery were analyzed and potential solutions to enhance treatment efficiency were explored. Results The mean spill time and mean cycle time per iso-energy slice (IES) for proton radiotherapy with beam gating technology were (2.98±1.98) s and (5.71±4.51) s, which were longer than the radiotherapy without using gating technology. The mean total cycle time for treatment without using gating technology was approximately 7 min for both proton and carbon ion beams. The mean total cycle time for lung cancer treatment using gating technology was approximately 15 min. Conclusion Application of mini-ridge filter or ripple filter to reduce per IES numbers and use of passive breath hold technology to eliminate interruptions during beam delivery in each IES for gating radiotherapy are two feasible approaches to improve treatment efficiency for this specific machine.
Zhao Jun,Li Yongqiang,Wu Xianwei et al. A theoretical investigation on improving the treatment efficiency based on timing characteristics for a proton-and-carbon ion treatment facility[J]. Chinese Journal of Radiation Oncology, 2020, 29(11): 996-999.
[1] Jiang GL. Particle therapy for cancers:a new weapon in radiation therapy[J]. Front Med, 2012, 6(2):165-172. DOI:10.1007/s11684-012-0196-4. [2] Schardt D, Elsässer T, Schulz-Ertner D. Heavy-ion tumor therapy:Physical and radiobiological benefits[J]. Rev Modern Phys, 2010, 82(1):383. DOI:10.1103/RevModPhys.82.383. [3] Jäkel O, Schulz-Ertner D, Karger C, et al. Heavy ion therapy:status and perspectives[J]. Technol cancer res treat, 2003, 2(5):377-387. DOI:10.1177/153303460300200503. [4] Owen H, Lomax A, Jolly S. Current and future accelerator technologies for charged particle therapy[J]. Nucl Instru. Methods Phys Res A, 2016, 809:96-104. DOI:10.1016/j.nima.2015.08.038. [5] Degiovanni A, Amaldi U. History of hadron therapy accelerators[J]. Phys Med, 2015, 31(4):322-332. DOI:10.1016/j.ejmp.2015.03.002. [6] Flanz J. Accelerators for charged particle therapy[J]. Modern Phys Lett A, 2015, 30(17):1540020. DOI:10.1142/s0217732315400209. [7] Akagi T, Higashi A, Tsugami H, et al. Ridge filter design for proton therapy at Hyogo Ion Beam Medical Center[J]. Phys Med Biol, 2003, 48(22):N301. DOI:10.1088/0031-9155/48/22/n01. [8] Kostjuchenko V, Nichiporov D, Luckjashin V. A compact ridge filter for spread out Bragg peak production in pulsed proton clinical beams[J]. Med Phys, 2001, 28(7):1427-1430. DOI:10.1118/1.1380433. [9] Li Y, Zhang X, Dong L, et al. A novel patch-field design using an optimized grid filter for passively scattered proton beams[J]. Phys Med Biol, 2007, 52(12):N265. DOI:10.1088/0031-9155/52/12/N01. [10] Newhauser WD, Myers KD, Rosenthal SJ, et al. Proton beam dosimetry for radiosurgery:implementation of the ICRU Report 59 at the Harvard Cyclotron Laboratory[J]. Phys Med Biol, 2002, 47(8):1369. DOI:10.1088/0031-9155/47/8/310. [11] Titt U, Mirkovic D, Sawakuchi GO, et al. Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency[J]. Phys Med Biol, 2010, 55(23):7097. DOI:10.1088/0031-9155/55/23/S10. [12] Li XA, Stepaniak C, Gore E. Technical and dosimetric aspects of respiratory gating using a pressure-sensor motion monitoring system[J]. Med Phys, 2006, 33(1):145-154. DOI:10.1118/1.2147743. [13] Trbojevic D, Alessi J, Blaskiewicz M, et al. Lattice design of a rapid cycling medical synchrotron for carbon/proton therapy[C]//Proceedings of IPAC. San Sebastián, 2011:2541-2543. [14] Al Harbi N, Lee S. Design of a compact synchrotron for medical applications[J]. Rev Sci Instrum, 2003, 74(4):2540-2545. DOI:10.1063/1.1561598. [15] Peggs S, Barton D, Beebe-Wang J, et al. The rapid cycling medical synchrotron, RCMS[C]//Proceedings of the European particle accelerator conference. Lucerne, 2002:2754-2756. [16] Hu W, Li G, Ye J, et al. Passive breath gating equipment for cone beam CT-guided RapidArc gastric cancer treatments[J]. Radiother Oncol, 2015, 114(1):104-108. DOI:10.1016/j.radonc.2014.11.046.