微生物在放射性口腔黏膜炎中作用的研究进展

doi:10.3760/cma.j.cn113030-20190227-00068

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摘要放射性口腔黏膜炎(ROM)是头颈部肿瘤放疗后最常见不良反应之一。ROM会引起患者口腔疼痛、进食困难、营养不良,甚至导致治疗中断。近年来,口腔微生物在ROM中作用逐渐受到重视。故针对ROM临床表现、发病机制,及微生物在ROM中的研究进展、机制通路和益生菌治疗进行综述。

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	舒泽凯
	赖淑贞
	陈媛媛
	陈明

关键词 ：微生物, 放射性口腔黏膜炎, 头颈部肿瘤/放射疗法

Abstract：Radiation-induced oral mucositis (ROM) is one of the most common adverse events after radiotherapy for head and neck cancer, which may result in oral pain, dysphagia, poor nutrition or even radiotherapy interruption. Recently, increasing attention has been paid to the role of microorganisms in ROM. In this review, the pathogenesis and clinical manifestations of ROM, the role of microorganism in ROM and its mechanism and probiotic therapy were summarized.

Key words： Microorganism Radiation-induced oral mucositis Head and neck neoplasm/radiotherapy

收稿日期: 2019-02-27

通讯作者: 陈媛媛,Email:chenyy@zjcc.org.cn

引用本文:

舒泽凯,赖淑贞,陈媛媛等. 微生物在放射性口腔黏膜炎中作用的研究进展[J]. 中华放射肿瘤学杂志, 2020, 29(8): 695-698.

Shu Zekai,Lai Shuzhen,Chen Yuanyuan et al. Research progress on the role of microorganisms in radiation-induced oral mucositis[J]. Chinese Journal of Radiation Oncology, 2020, 29(8): 695-698.

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