基于肠道菌群的肠放射损伤生物标记物研究进展

doi:10.3760/cma.j.issn.1004-4221.2020.03.018

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摘要近年来,肠道菌群及其代谢物与肿瘤发生、炎性肠病、肠道放射损伤的关系越来越受到研究者重视。源于核事故调查、临床研究、动物模型探索等多种证据证实,肠道菌群及其代谢物可作为评估肠道放射损伤暴露水平与严重程度的生物标记物。本文综述肠道菌群及其代谢物与肠道受照剂量、放射损伤的关系,为评估肠道放射损伤风险提供理论参考。

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	张军军
	蔡尚
	杨咏强
	李俊彦
	田野

关键词 ：肠道菌群, 代谢物, 放射损伤, 生物标记物

Abstract：Recently,the relationship between intestinal flora and its metabolites and tumorigenesis,inflammatory bowel diseasesas well as radiation-induced intestinal injury has captivated widespread attention from researchers. Accumulated evidence derived from nuclear accident investigation,animal model experiment and clinical research has proven the role of intestinal flora and its metabolites as the biomarkers to evaluate the radiation dose and severity of radiation-induced intestinal injury. This article reviews the relationship between intestinal flora and its metabolites and radiation-induced intestinal injury, aiming to provide theoretical reference for assessing the risk of radiation-induced intestinal injury.

Key words： Intestinal flora Metabolite Radiation-induced injury Biomarker

收稿日期: 2018-11-03

基金资助:江苏省医学创新团队(CXDT-37);苏州市科技发展计划(SZS201509);苏大附二院博士预研基金(SDFEYBS1701)

通讯作者: 田野,Email:dryetian@126.com

引用本文:

张军军,蔡尚,杨咏强等. 基于肠道菌群的肠放射损伤生物标记物研究进展[J]. 中华放射肿瘤学杂志, 2020, 29(3): 237-240.

Zhang Junjun,Cai Shang,Yang Yongqiang et al. Research progress on biomarkers for radiation-induced intestinal injury based on intestinal flora[J]. Chinese Journal of Radiation Oncology, 2020, 29(3): 237-240.

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http://journal12.magtechjournal.com/Jweb_fszlx/CN/10.3760/cma.j.issn.1004-4221.2020.03.018 或 http://journal12.magtechjournal.com/Jweb_fszlx/CN/Y2020/V29/I3/237

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