[an error occurred while processing this directive]
中华放射肿瘤学杂志
   2025年4月7日 星期一     首 页 |  期刊介绍  |  编 委 会  |  投稿指南  |  期刊订阅  |  广告合作  |  学术影响  |  收录情况  |  联系我们  |  English
中华放射肿瘤学杂志  2020, Vol. 29 Issue (3): 175-178    DOI: 10.3760/cma.j.issn.1004-4221.2020.03.004
胸部肿瘤 最新目录| 下期目录| 过刊浏览| 高级检索 [an error occurred while processing this directive]|[an error occurred while processing this directive]
局限期小细胞肺癌放化疗后局部区域复发模式分析
颜文彬, 刘璇, 周宗玫, 王玉霞, 肖泽芬, 冯勤付, 陈东福, 吕纪马, 梁军, 邓垒, 张涛, 王文卿, 毕楠, 王鑫, 王小震, 惠周光, 王绿化
国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021
Analysis of local recurrence pattern for limited stage small cell lung cancer after IMRT plus chemotherapy
Yan Wenbin, Liu Xuan, Zhou Zongmei, Wang Yuxia, Xiao Zefen, Feng Qinfu, Chen Dongfu, LüJima, Liang Jun, Deng Lei, Zhang Tao, Wang Wenqing, BI Nan, Wang Xin, wang xiaozhen, Hui Zhouguang, Wang Luhua
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021,China
全文: PDF (0 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      背景资料
摘要 目的 分析精确放疗技术下局限期小细胞肺癌(SCLC)调强放化疗后局部区域复发模式、复发部位与放化疗关系及影响因素。方法 回顾分析中国医学科学院肿瘤医院于2006-2014年治疗的局限期SCLC患者482例,其中125例治疗局部区域复发,采用Kaplan-Meier生存分析,Logrank法检验差异和单因素分析影响因素,Logistic回归法多因素分析影响因素。结果 全组复发患者的1、2、5年生存率分别为92.0%、46.4%、14.7%,中位生存期23.40个月。中位进展时间12.96个月,复发后的中位生存期为11.50个月,1、2、5年生存率分别为45.0%、23.0%、10.0%。原发灶复发67例(53.6%)、区域淋巴结复发21例(16.8%)、原发灶+区域淋巴结复发28例(22.4%)、对侧纵隔或锁骨上淋巴结复发9例(7.2%),其中位生存期分别为23.96、24.76、23.23、18.66个月,2年生存率分别为49%、52%、46%、11%(P=0.000、0.004、0.008)。6例(4.0%)患者靶区外孤立淋巴结复发,其中5例位于锁骨上区域,1例(0.8%)野外孤立淋巴结复发。结论 局限期SCLC放化疗后局部失败部位主要为肺原发灶,更好的分割剂量和靶区范围需要进一步的临床探索。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
颜文彬
刘璇
周宗玫
王玉霞
肖泽芬
冯勤付
陈东福
吕纪马
梁军
邓垒
张涛
王文卿
毕楠
王鑫
王小震
惠周光
王绿化
关键词 肺肿瘤/放化疗法放射疗法,调强复发模式    
AbstractObjective To investigate localized regional recurrence after chemotherapy and chest radiotherapy in limited stage small cell lung cancer (LS-SCLC),and explore the relationship between recurrence location and radiotherapy and chemotherapy and its influencing factors.Methods From 2006 to 2014,pathological LS-SCLC treated in CAMS,125 patients had local recurrence,Kaplan-Meier statistical method was used to analyze the survival rate and PFS of each recurrence site. Log-rank was used to compare the survival rate of each group. Univariate analysis includes Chi-squareand t-test for the factors for the recurrence site. Multivariate analysis using Logistic regression.Results The 1-,2-and 5-year overall survival rates were 92.0%,46.4% and 14.7%,respectively. The median progression time was 12.96 months,The median survival time after progression was 11.5 months,and the 1-,2-,and 5-year overall survival rates were 45.0%,23.0%,and 10.0%,respectively. The recurrence sites include intrapulmonary recurrence (67 patients),regional lymph nodes (21 patients),simultaneous intrapulmonary and regional lymph nodes (28 patients), and contralateral or supraclavicular lymph nodes (9 patients). The median survival time were 23.96 months,24.76 months,23.23 months,and 18.66 months,and the 2-year survival rates were 49%,52%,46%,and11%,respectively (P=0.000,0.004,0.008). In 6 patients (4.0%),5 patients were located in the supraclavicular region,and 1 patient (0.8%) in the field.Conclusions For LS-SCLC undergoing IMRT and chemotherapy,the local failure location is mainly located in the pulmonary,and further treatment of the split dose and targets requires further clinical exploration.
Key wordsLung neoplasms/radiochemoradiation    Radiotherapy,intensity-modulated    Patterns of failure   
收稿日期: 2019-11-25     
通讯作者: 周宗玫,Email:zhouzongmei2013@163.com   
引用本文:   
颜文彬,刘璇,周宗玫等. 局限期小细胞肺癌放化疗后局部区域复发模式分析[J]. 中华放射肿瘤学杂志, 2020, 29(3): 175-178.
Yan Wenbin,Liu Xuan,Zhou Zongmei et al. Analysis of local recurrence pattern for limited stage small cell lung cancer after IMRT plus chemotherapy[J]. Chinese Journal of Radiation Oncology, 2020, 29(3): 175-178.
链接本文:  
http://journal12.magtechjournal.com/Jweb_fszlx/CN/10.3760/cma.j.issn.1004-4221.2020.03.004     或     http://journal12.magtechjournal.com/Jweb_fszlx/CN/Y2020/V29/I3/175
京公网安备11010502022167号
版权所有 © 2010《中华放射肿瘤学杂志》编辑部
地址:北京朝阳区潘学园南里17号 中国医学科学院肿瘤医院(100021)
电话:010-67700737,87788294 Email: cjron@cmaph.org
本系统由北京玛格泰克科技发展有限公司设计开发 技术支持:Support@magtech.com.cn