3D打印非共面模版引导<sup>125</sup>I粒子植入治疗头颈部肿瘤个体化设计与应用

doi:10.3760/cma.j.issn.1004-4221.2020.01.010

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摘要目的对比3D打印非共面模板引导¹²⁵I粒子植入治疗头颈部肿瘤的术前、术后计划的物理剂量学参数,探索头颈部肿瘤放射性粒子植入治疗用个体化模板设计方法的安全性、可行性、精确性。方法 2016年1月-2016年12月于北京大学第三医院接受3D打印模板辅助CT引导放射性¹²⁵I粒子植入的头颈部复发/转移恶性肿瘤的患者42例。处方剂量110~160Gy,设计制作3D打印非共面模板42块,对比术前、术后物理剂量学参数,包括D90、最小周边剂量(mPD)、V100、V150、V200、适形指数(CI)、靶区外体积指数(EI)、均匀性指数(HI)。结果为42例患者设计、制作的42块导板术中就位良好,与术前计划相比,术后D90、V100、CI、EI、HI均相近(P=0.490、0.407、0.893、0.143、0.079),mPD、V150、V200不同(P=0.036、0.007、0.000)。结论术后验证的主要剂量学指标较好地达到了术前计划要求,有良好的治疗精确性,可以满足临床需求。

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	崔悦
	孙海涛
	姜玉良
	王俊杰

关键词 ：三维打印, 个体化非共面模板, 剂量学, 头颈部肿瘤/放射性粒子植入

Abstract：Objective To compare the dosimetric data between preoperative plans and postoperative verification in computed tomography (CT)-guided and 3D-printing non-coplanar template-assisted ¹²⁵I seed implantation for head and neck tumor, aiming to explore the safety, feasibility and accuracy of the individualized template design method. Methods A total of 42 patients with recurrent/metastatic malignant head and neck tumor admitted toPeking University Third Hospitalfrom January to December 2016 were recruited in this study. A prescribed dose of 110-160Gy was adopted.3D-printing non-coplanar templates were designed for 42 cases. The dosimetric parameters including D90,minimum peripheral dose (mPD),V100,V150,V200,conformal index (CI),external index (EI) and homogeneity index (HI) were statistically compared before and after surgery. Results All templates were properly implanted intraoperatively. Compared with preoperative planning, postoperative D90,V100,CI,EI and HI did not significantly differ (P=0.490, 0.407, 0.893, 0.143 and 0.079), whereas mPD,V150 and V200 significantly differed (P=0.036, 0.007 and 0.000). Conclusion After postoperative verification, the main dosimetric parameters have high therapeutic accuracy and properly match with preoperative planning, which can meet clinical requirements.

Key words： Three-dimensional printing Individualized non-coplanar template Dosimetry Head and neck neoplasm/radioactive seed implantation

收稿日期: 2018-06-14

通讯作者: 王俊杰,Email:junjiewang_edu@sina.cn

引用本文:

崔悦,孙海涛,姜玉良等. 3D打印非共面模版引导¹²⁵I粒子植入治疗头颈部肿瘤个体化设计与应用[J]. 中华放射肿瘤学杂志, 2020, 29(1): 43-46.

Cui Yue,Sun Haitao,Jiang Yuliang et al. 3D-printing non-coplanar template assisted ¹²⁵I seed implantation for head and neck tumor:individualized template design and application[J]. Chinese Journal of Radiation Oncology, 2020, 29(1): 43-46.

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[1]Meng N,Jiang YL,Wang JJ,et al. Permanent implantation of iodine-125 seeds as a salvage therapy for recurrent head and neck carcinoma after radiotherapy[J]. Cancer Invest,2012,30(3):236-242. DOI:10.3109/07357907.2012.654869.
[2]Wang ZM,Lu J,Liu T,et al. CT-guided interstitial brachytherapy of inoperable non-small cell lung cancer[J]. Lung Cancer,2011,74(2):253-257. DOI:10.1016/j.lungcan.2011.03.006.
[3]Wang H,Wang JJ,Jiang YL,et al. The investigation of ¹²⁵I seed implantation as a salvage modality for unresectable pancreatic carcinoma[J]. J Exp Clin Cancer Res,2013,32(1):106-113. DOI:10.1186/1756-9966-32-106.
[4]Wang JJ,Yuan HS,Li JN,et al. Interstitial permanent implantation of ¹²⁵I seeds as salvage therapy for re-recurrent rectal carcinoma[J]. Int J Colorectal Dis,2009,24(4):391-399. DOI:10.1007/s00384-008-0628-4.
[5]刘树铭,张建国,黄明伟,等. 个体化模板辅助颅底区永久性组织间近距离治疗的可行性研究[J]. 中华放射医学与防护杂志,2013,33(1):42-45. DOI:10.3760/cma.j.issn.0254-5098.2013.01.011.
Liu S, Zhang J, Huang M, et al. Feasibility of permanent interstitial brachytherapy for skull base region through individual template assistance[J]. Chin J Radiol Med Prot, 2013,33(1):42-45. DOI:10.3760/cma.j.issn.0254-5098.2013.01.011.
[6]赵一姣,王勇,黄明伟,等. 近距离放射治疗用个性化导板的数字化设计方法[J]. 中华口腔医学杂志,2014,49(2):115-118. DOI:10.3760/cma.j.issn.1002-0098.2014.02.011.
Zhao Y, Wang Y, Huang M, et al. Method about digital design of individual template for brachytherapy[J]. Chin J Stomal, 2014,49(2):115-118. DOI:10.3760/cma.j.issn.1002-0098.2014.02.011.
[7]赵楠,杨瑞杰,王俊杰.¹²⁵I放射性粒子植入计划定制研究[J]. 中华放射医学与防护杂志,2014,(1):54-58. DOI:10.3760/cma.j.issn.0254-5098.2014.01.015.
Zhao N, Yang R, Wang J. Customized planning for radioactive ¹²⁵I seed implantation[J]. Chin J Radiol Med Prot,2014,(1):54-58. DOI:10.3760/cma.j.issn.0254-5098.2014.01.015.
[8]Nag S,Beyer D,Friedland J,et al. American brachytherapy society (ABS) recommendations for transperineal permanent brachytherapy of prostate cancer[J]. Int J Radiat Oncol Biol Phys,1999,44(4):789-799. DOI:10.1016/s0360-3016(99)00069-3.
[9]霍彬,侯朝华,叶剑飞,等. CT引导术中实时计划对胸部肿瘤125Ⅰ粒子植入治疗的价值[J]. 中华放射肿瘤学杂志,2013,22(5):400-402. DOI:10.3760/cma.j.issn.1004-4221.2013.05.019.
Huo B, Hou Z, Ye J, et al. The study of intraoperative real-time planning by CT-guided in ¹²⁵I seed implantation for thoracic malignancies[J]. Chin J Radiat Oncol, 2013,22(5):400-402. DOI:10.3760/cma.j.issn.1004-4221.2013.05.019.
[10]孙海涛,姚丽红,王俊杰,等.3D打印非共面模板引导¹²⁵I粒子组织间近距离治疗盆腔肿瘤个体化设计[J]. 中华放射医学与防护杂志,2017,37(7):485-489. DOI:10.3760/cma.j.issn.0254-5098.2017.07.002.
Sun H, Yao L, Wang J, et al. 3D-printing non-coplanar template assisted ¹²⁵I seed for pelvic tumor:individual template design method[J]. Chin J Radiol Med Prot, 2017,37(7):485-489. DOI:10.3760/cma.j.issn.0254-5098.2017.07.002.
[11]姜玉良,李宾,吉喆,等.3D打印个体化非共面模板辅助粒子植入时定位与复位误差研究[J]. 中华放射医学与防护杂志,2016,36(12):913-916. DOI:10.3760/cma.j.issn.0254-5098.2016.12.007.
Jiang Y, Li B, Ji Z, et al. Analysis of position errors of 3D printing individual non-coplanar template for radioactive seed implantation for malignant tumor[J]. Chin J Radiol Med Prot, 2016,36(12):913-916. DOI:10.3760/cma.j.issn.0254-5098.2016.12.007.
[12]李客楼,李宗安,朱莉娅,等.3D打印技术在医疗领域的应用进展[J]. 机械设计与制造工程,2016,45(9):11-16. DOI:10.3969/j.issn.2095-509X.2016.09.002.
Li K, Li Z, Zhu L, et al. Application of 3D printing technology in medical field[J]. Mach Des Manuf Eng, 2016,45(9):11-16. DOI:10.3969/j.issn.2095-509X.2016.09.002.