48例宫颈残端恶性肿瘤预后因素分析

doi:10.3760/cma.j.issn.1004-4221.2019.11.009

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摘要

目的探讨影响宫颈残端恶性肿瘤不良预后因素,为临床诊疗提供一定参考。方法回顾分析2005-2016年间本医院收治的 48例宫颈残端恶性肿瘤患者临床资料。ⅠA-ⅡA期 19例(40%)以手术+辅助治疗为主,ⅡB-Ⅳ期 29例(60%)以放化疗为主。中位发病年龄 51岁,子宫次全切除原因以子宫肌瘤为主,距子宫次全切除平均时间10.76年。结果 1、3、5年生存率分别为98%、83%、74%。单因素分析显示距子宫次全切除时间(P=0.016)、肿瘤直径(P=0.016)、临床分期(P=0.036)、组织学分级(P=0.009)、淋巴结转移(P=0.044)、宫旁受侵(P=0.046)、骨髓抑制(P=0.013)、根治性手术(P=0.019)为不良预后影响因素。结论宫颈残端恶性肿瘤不良预后与肿瘤直径、临床分期、组织学分级、淋巴结转移、宫旁受侵、骨髓抑制有关,其中组织学分级是独立危险因素。

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	穆叶赛
	阿依努尔·色义提
	古丽娜·库尔班

关键词 ：宫颈残端, 恶性肿瘤/放化疗法, 预后

Abstract：

Objective To explore the poor prognostic factors of patients with cervical stump carcinoma, aiming to provide certain reference for the clinical diagnosis and treatment. Methods Clinical data of 48 patients with cervical stump carcinoma admitted to the Affiliated Tumor Hospital of Xinjiang Medical University from January 1, 2005 to December 1, 2016 were retrospectively analyzed. A total of 19 patients (40%) withⅠA-ⅡA stage cervical stump carcinoma were treated with surgery+ adjuvant therapy and 29 patients (60%) in ⅡB-Ⅳ stage received radiotherapy combined with chemotherapy. The median age of onset was 51 years old. Uterine fibroids were the main cause of subtotal hysterectomy. The average time interval from subtotal hysterectomy to definite diagnosis was 10.76 years. Results The 1-,3-,5-year survival rate was 98%,83% and 74%,respectively. Univariate analysis demonstrated the time interval from subtotal hysterectomy (P=0.016), tumor diameter (P=0.016), clinical stage (P=0.036), histological grade (P=0.009),lymph node metastasis (P=0.044), parametrial invasion (P=0.046), myelosuppression (P=0.013) and radical surgery (P=0.019) were the poor prognostic factors of cervical stump carcinoma. Conclusions Poor prognosis of patients with cervical stump carcinoma is correlated with tumor diameter, clinical stage, histological grade, lymph node metastasis, parametrial invasion and myelosuppression. Histological grade is an independent risk factor.

Key words： Cervical stump Malignant neoplasm/radiochemotherapy Prognosis

收稿日期: 2019-08-15

通讯作者: 古丽娜·库尔班,Email:gulinakurb@126.com

引用本文:

穆叶赛,阿依努尔·色义提,古丽娜·库尔班. 48例宫颈残端恶性肿瘤预后因素分析[J]. 中华放射肿瘤学杂志, 2019, 28(11): 840-842.

Mu Yesai,Ayinuer·Seyiti,Gulina·Kuerban. Analysis of the poor prognostic factors affecting 48 cases of cervical stump carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(11): 840-842.

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http://journal12.magtechjournal.com/Jweb_fszlx/CN/10.3760/cma.j.issn.1004-4221.2019.11.009 或 http://journal12.magtechjournal.com/Jweb_fszlx/CN/Y2019/V28/I11/840

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