Effect of different nutritional support methods on esophageal cancer patients receiving radiotherapy
Cheng Guowei1, Sun Li1, Zhang Tao2, Chen Ping1, He Xiangling1, Su Dan1, Xi Hengzhi1, Zang Dingqi1
1Department of Radiation Oncology,Cancer Hospital of Huanxing Chaoyang District Beijing,Beijing 100122,China; 2Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences ( CAMS ) and Peking Union Medical College ( PUMC),Beijing 100021,China
Abstract：Objective To compare the effect of nutritional support with and without tube feeding on the incidence of adverse reactions in radiotherapy for esophageal cancer. Methods A total of 120 esophageal cancer patients with high-risk factors receiving radiotherapy were selected and randomly assigned into the tube feeding (TF,n=60) and non-tube feeding groups (NTF,n=60) according to the random number method. Nutritional interventions were performed during radiotherapy in both groups. The incidence of esophagitis and myelosuppression,pulmonary infection,nutritional status and the completion of radiotherapy were observed and statistically compared between TF and NTF groups. Results In the TF group,the incidence of ≥ grade 2 esophagitis was lower than that in the NTF group. The incidence of grade 3 esophagitis significantly differed between two groups (P<0.05). The incidence of grade 1-2 myelosuppression did not differ between two groups,whereas the incidence of grade 3 myelosuppression in the TF group was significantly lower than that in the NTF group (P<0.05). In the TF group,the incidence of pulmonary infection was remarkably lower than that in the NTF group (P<0.05). The changes of BMI and prealbumin in the TF group were better than those in the NTF group (both P<0.05). One patient in the NTF group failed to complete the radiotherapy due to grade IV esophagitis,and 5 cases in the NTF group (P<0.05). In the TF group,the length of hospital stay was significantly shortened by 6.2 d on average (P<0.05). Conclusions During radiotherapy for esophageal cancer patients with high-risk factors,nutritional support with tube feeding can effectively reduce the incidence of adverse reactions,improve the completion rate of treatment,and shorten the average length of hospital stay.
Cheng Guowei,Sun Li,Zhang Tao et al. Effect of different nutritional support methods on esophageal cancer patients receiving radiotherapy[J]. Chinese Journal of Radiation Oncology, 2019, 28(7): 505-508.
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