[an error occurred while processing this directive]|[an error occurred while processing this directive]
局限期小细胞肺癌胸部放疗剂量和分割方式研究进展
许锦彪1, 邱峰2
1赣州市肿瘤医院肿瘤科 341000; 2南昌大学第一附属医院肿瘤科 330006
Research progress on dosage and segmentation of thoracic radiotherapy for limited-stage small cell lung cancer
Xu Jinbiao1, Qiu Feng2
1Department of Oncology,Ganzhou Cancer Hospital,Ganzhou 341000,China; 2Department of Oncology,First Affiliated Hospital of Nanchang University,Nanchang 330006,Chian
Abstract：At present, surgery, systemic chemotherapy, thoracic radiotherapy and prophylactic cranial irradiation have been widely recognized to treat the limited-stage small cell lung cancer. In recent decades, no significant breakthrough has been reached in drug therapy. In the field of radiotherapy, the timing, target volume, mode of dose fractionation and prophylactic cranial irradiation are the hot issues. In this article, the research progress on the dose and the mode of dose fractionation for limited-stage small cell lung cancer was briefly analyzed.
Xu Jinbiao,Qiu Feng. Research progress on dosage and segmentation of thoracic radiotherapy for limited-stage small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(6): 463-466.
[1] Siegel R,Ma J,Zou Z,et al. Cancer statistics,2014[J].CA Cancer J Clin,2014,64(1):9-29.DOI:10.3322/caac.21208. [2] Okamoto K,Okamoto I,Takeda M,et al. A phase Ⅰ study of split-dose cisplatin and etoposide while concurrent accelerated hyperfractionated thoracic radiotherapy in elderly patients with limited-stage small-cell lung cancer[J].Jpn J Clin Oncol,2014,44(8):7438.DOI:10.1093/jjco/hyu071. [3] Ha IB,Jeong BK,Jeong H,et al. Effect of early chemoradiotherapy in patients with limited-stage small-cell lung cancer[J].Radiat Oncol J,2013,31(4):185-190.DOI:10.3857/roj.2013.31.4.185. [4] Palma DA,Senan S,Tsujino K,et al. Predicting radiation pneumonitis after chemoradiation therapy for lung cancer:an international individual patient data meta-analysis[J].Int J Radiat Oncol Biol Phys,2013,85(2):444-450.DOI:10.1016/j.ijrobp.2012.04.043. [5] Palma DA,Senan S,Oberije C,et al. Predicting esophagitis after chemoradiation therapy for non-small cell lung cancer:an individual patient data meta-analysis[J].Int J Radiat Oncol Biol Phys,2013,87(4):690-696.DOI:10.1016/j.ijrobp.2013.07.029. [6] Kim T H,Cho KH,Hong RP,et al. Dose-volumetric parameters of acute esophageal toxicity in patients with lung cancer treated with three-dimensional conformal radiotherapy[J].Int J Radiat Oncol Biol Phys,2005,62(4):995-1002.DOI:10.1016/j.ijrobp.2004.12.025. [7] Tada T,Minakuchi K,Koda M,et alLimited-stage small cell lung cancer:local failure after chemotherapy and radiation therapy[J].Radiology,1998,208(2):511-515.DOI:10.1148/radiology.208.2.9680584. [8] Schild SE,Bonner JA,Hillman S,et alResults of a phase Ⅱ study of high-dose thoracic radiation therapy with concurrent cisplatin and etoposide in limited-stage small-cell lung cancer (NCCTG 95-20-53)[J].J Clin Oncol,2007,25(21):3124-3129.DOI:10.1200/JCO.2006.09.9606. [9] Xia B,Chen GY,Cai XW,et al. The effect of bioequivalent radiation dose on survival of patients with limited-stage small-cell lung cancer[J].Radiat Oncol,2011,6(1):50-59.DOI:10.1186/1748-717X-6-50. [10] Zhu L,Zhang S,Xu X,et al. Increased biological effective dose of radiation correlates with prolonged survival of patients with limited-stage small cell lung cancer:a systematic review[J/OL].Plos One,2016,11(5):e0156494.DOI:10.1371/journal.pone.0156494. [11] Bayman NA,Sheikh H,Kularatne B,et al. Radiotherapy for small-cell lung cancer—Where are we heading?[J].Lung Cancer,2009,63(3):307-314.DOI:10.1016/j.lungcan.2008.06.013. [12] Zahra A,Chang T,Hejleh T A,et al. Once daily high-dose radiation (≥60 Gy) treatment in limited stage small cell lung cancer[J].J Oncol Transl Res,2016,2(1):108-115.DOI10.4172/2476-2261.1000108. [13] Salama JK,Hodgson L,Pang H,et al. A pooled analysis of limited-stage small-cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy:CALGB 30904[J].J Thorac Oncol,2013,8(8):1043-1049.DOI:10.1097/JTO.0b013e318293 d8a4. [14] Salama JK,Hodgson L,Pang H,et al. A pooled analysis of limited-stage small-cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy:CALGB 30904[J].J Thorac Oncol,2013,8(5):1043-1049.DOI:10.1097/JTO.0b013e318293 d8a4. [15] Komaki R,Paulus R,Ettinger DS,et al. Phase Ⅱ study of accelerated high-dose radiotherapy with concurrent chemotherapy for patients with limited small-cell lung cancer:Radiation Therapy Oncology Group protocol 0239[J].Int J Radiat Oncol Biol Phys,2012,83(4):e531-536.DOI:10.1016/j.ijrobp.2012.01.07. [16] Rutter CE,Park HS,Corso CD,et al. Comparison of survival outcomes among standard radiotherapy regimens in limited-stage small cell lung cancer patients receiving concurrent chemoradiation[J].Lung Cancer,2015,90(2):243-248.DOI:10.1016/j.lungcan.2015.08.002. [17] Han D,Qin Q,Hao S,et al. Feasibility and efficacy of simultaneous integrated boost intensity-modulated radiation therapy in patients with limited-disease small cell lung cancer[J].Radiat Oncol,2014,9(1):1-8.DOI:10.1186/s13014-014-0280-9. [18] 尤静,于会明,宋马小薇,石晨,王晓航,郑晔,余荣,石安辉,朱广迎.局限期小细胞肺癌同步推量调强放疗的Ⅰ期/Ⅱ期临床研究[J].中国肺癌杂志,2017,20(01):28-34.DOI:10.3779/j.issn.1009-3419.2017.01.04. You J,Huiming YU,Song M,et al. A Phase Ⅰ/Ⅱ study of chemotherapy concurrent with twice-daily radiotherapy schedules by intensity modulated radiation therapy using simultaneous integrated boost for limited-stage small cell lung cancer[J].Chin J Lung Cancer,2017,20(1):28-34.DOI:10.3779/j.issn.1009-3419.2017.01.04. [19] Komaki R,Paulus R,Ettinger DS,et al. Phase Ⅱ study of accelerated high-dose radiotherapy with concurrent chemotherapy for patients with limited small-cell lung cancer:radiation therapy oncology group protocol 0239[J].Int J Radiat Oncol Biol Phys,2012,83(4):e531-e536.DOI:10.1016/j.ijrobp.2012.01.07. [20] Turrisi ATⅢ,Kim K,Blum R,et alTwice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancel treated concurrently with cisplatin and etoposide[J].N Engl J Med,1999,340(2):265-271.DOI:10.1056/NEJM199901283400403. [21] Faivre-Finn C,Snee M,Ashcroft L,et al. Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT):an open-label,phase 3,randomised,superiority trial[J].Lancet Oncol,2017,18(8):1116-1125.DOI:10.1016/S1470-2045(17)30318-2. [22] Han D,Hao S,Tao C,et al. Comparison of once daily radiotherapy to 60 Gy and twice daily radiotherapy to 45 Gy for limited stage small-cell lung cancer[J].Thorac Cancer,2015,6(5):643-648.DOI:10.1111/1759-7714.12262. [23] 王伟力,钟文,刘大伟,等.胸部放疗分割与局限期小细胞肺癌失败模式的相关性研究[J].现代肿瘤医学,2017,25(2):216-219.DOI:10.3969/j.issn.1672-4992.2017.02.014. Wang WL,Zhong W,Liu DW,et al. Correlation between thoracic radiotherapy segmentation and failure patterns of small cell lung cancer in limited period[J].Mod Oncol Med,2017,25(2):216-219.DOI:10.3969/j.issn.1672-4992.2017.02.014. [24] Xia B,Hong LZ,Cai XW,et al. Phase 2 study of accelerated hypofractionated thoracic radiation therapy and concurrent chemotherapy in patients with limited-stage small-cell lung cancer[J].Int J Radia Oncol Biol Phys,2015,91(3):517-523.DOI:10.1016/j.ijrobp.2014.09.042. [25] Turgeon G A,Souhami L,Kopek N,et al. Thoracic irradiation in 3 weeks for limited-stage small cell lung cancer:Is twice a day fractionation really needed?[J].Cancer Radiother,2017,21(2):89-98.DOI:10.1016/j.canrad.2016.09.015. [26] Zhang J,Fan M,Liu D,et al. Hypo-or conventionally fractionated radiotherapy combined with chemotherapy in patients with limited stage small cell lung cancer[J].Radiat Oncol,2017,12(1):51-58.DOI:10.1186/s13014-017-0788-x. [27] Socha J,Guzowska A,Tyc-Szczepaniak D,et al. Accelerated hypofractionated thoracic radiotherapy in limited disease small cell lung cancer:comparison with the results of conventionally fractionated radiotherapy[J].J Balkan Union Oncol,2015,20(1):146-157.DOI:10.3969/j.issn.1671-8135.2006.12.020. [28] 夏冰,陈桂园,蔡旭伟,等.局限期小细胞肺癌不同剂量分割模式放疗的疗效分析[J].中华放射肿瘤学杂志,2010,19(6):496-499.DOI:10.3760/cma.j.issn.1004-4221.2010.06.006. Xia B,Chen GY,Cai XW,et al. Analysis of the curative effect of different dosage segmentation mode radiotherapy in small cell lung cancer with limited duration[J].Chin J Radiat Oncol,2010,19(6):496-499.DOI:10.3760/cma.j.issn.1004-4221.2010.06.006. [29] Grønberg BH,Halvorsen TO,FløttenØ,et al. Randomized phase Ⅱ trial comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy in limited disease small cell lung cancer[J].Acta Oncol,2016,55(5):591-597.DOI:10.3109/0284186X.2015.1092584. [30] Bettington C S,Tripcony L,Bryant G,et al. A retrospective analysis of survival outcomes for two different radiotherapy fractionation schedules given in the same overall time for limited stage small cell lung cancer[J].J Med Imag Radiat Oncol,2013,57(1):105-1 12.DOI:10.1111/j.1754-9485.2012.02470.x. [31] National comprehensive cancer network. NCCN clinical practice guidelinesin oncology:small cell lung cancer (version1.2016)[M].Washington:NCCN,2016.
2019, Vol. 28 
