[an error occurred while processing this directive]|[an error occurred while processing this directive]
X (γ)射线全身照射过程中患者全身剂量分布的蒙特卡罗模拟
刘渊渊1, 吴爱东2, 刘红冬1, 齐雅平1, 陈志1, 徐榭1
1中国科学技术大学,合肥 230027; 2安徽省立医院放疗科,合肥 230001;
Monte Carlo simulation of whole body dose distribution in patients with total body X (γ) ray irradiation
Liu Yuanyuan1, Wu Aidong2, Liu Hongdong1, Qi Yaping1, Chen Zhi1, Xu Xie1
1University of Science and Technology of China, Hefei 230027, China; 2Department of Radiation Oncology, Anhui Provincial Hospital, Hefei 230001, China;
Abstract： Objective To explore the feasibility of application of the Monte Carlo method to simulate the whole body dose distribution in patients with total body X (γ) ray irradiation by comparing the actual measurement results. Methods A Monte Carlo model of a 6 MV Elekta Synergy Clinical linear accelerator was established by MCNPX. According to the relationship between the CT value and the density of the material, the CT of the ATOM physical phantom was converted into a voxel phantom for MCNPX calculation. The dose distribution of the whole body was simulated in the total body X (γ) ray irradiation. The simulated results were compared with the measurement values of the thermoluminescence dosimetry at different positions in the ATOM physical phantom to analyze the differences. Results The difference between the depth dose curve and the off-axis dose curve and the actual measurement values calculated by the 6 MV accelerator treatment head model in the water tank was less than 2%,with the maximum dose depth of approximately 1.5 cm and field size of 10 cm×10 cm, which were consistent with the actual measurement values. The maximum difference between the simulated results at different locations in the body and the thermoluminescence dosimeter was approximately 4%, and the simulated results of MCNPX were almost in good agreement with the results of thermoluminescence. Conclusions The whole body dose distribution in patient with total body X (γ) ray irradiation can be accurately simulated by MCNPX. Monte Carlo simulation makes it possible to optimize the uniformity of the total body dose during the total body irradiation process.
刘渊渊,吴爱东,刘红冬等. X (γ)射线全身照射过程中患者全身剂量分布的蒙特卡罗模拟[J]. 中华放射肿瘤学杂志, 2019, 28(1): 47-51.
Liu Yuanyuan,Wu Aidong,Liu Hongdong et al. Monte Carlo simulation of whole body dose distribution in patients with total body X (γ) ray irradiation[J]. Chinese Journal of Radiation Oncology, 2019, 28(1): 47-51.
[1] Van DJ,Galvin JM,Glasgow GP,et al. Physical aspects of total and half body irradiation[J]. AAPM Report, 1986, 17. https://www.aapm.org/pubs/reports/RPT_17.pdf. [2] 胡逸民.肿瘤放射物理学[M].北京:原子能出版社,2003. Hu YM. Radiation Oncology Physics[M].Beijing:Atomic energy press,2003. [3] 冯宁远.实用放射治疗物理学[M].北京:北京医科大学中国协和医科大学联合出版社,1998. Feng NY.Practical radiotherapy physics[M].Beijing:Beijing medical university,Peking union medical college united Press,1998. [4] 许淑艳.蒙特卡罗方法在实验核物理中的应用[M].北京:原子能出版社,2006. Xu SY.Application of Monte Carlo method in experimental nuclear physics[M].Beijing:Atomic energy press,2006. [5] Pelowitz D,MCNPXTM User's Manual,Version 2.7.0,LA-CP-11-00438(2011).ATOM? Dosimetry Phantoms[DB/OL][2017-07-22].http://www.cirsinc.com/products/all/33/atom-dosimetry-verification-phantoms/.pdf. [6] van Dyk J.Dosimetry for total body irradiation[J].Radiother Oncol,1987,9(2):107-118.DOI:10.1016/S0167-8140(87)80198-6. [7] Galvin JM.Calculation and prescription of dose for total body irradiation[J].Int J Radiat Oncol Biol Phys,1983,9(12):1919-1924.DOI:10.1016/0360-3016(83)90363-2. [8] Abraham D,Colussi V,Shina D,et al. TBI treatment planning using the ADAC pinnacle treatment planning system[J].Med Dosim,2001,25(4):219-224.DOI:10.1016/S0958-3947(00)00049-2. [9] 江波.基于常规加速器的全身调强放疗方法[D].北京:北京协和医学院(中国医学科学院),2010:45-48. Jiang B.The method of systemic intensity modulated radiotherapy based on conventional accelerator[D].Beijing:Peking union medical college (Chinese Academy of Medical Sciences),2010:45-48. [10] Ribas M,Jornet N,Eudaldo T,et al. Midplane dose determination during total body irradiation using in vivo dosimetry[J].Radiother Oncol,1998,49(1):91-98.DOI:10.1016/S0167-8140(98)00094-2. [11] 张绍刚,刘明远,朱庙生,等.对三种全身放射治疗技术的分析[J].中华放射肿瘤学杂志,1994(4):279-280. Zhang SG,Liu MY,Zhu MS,et al. Analysis of three systemic radiotherapy techniques[J].Chin J Radiat Oncol,1994(4):279-280. [12] 张九堂,伍志红,鲁旭蔚,等.直线加速器全身照射技术[J].中国医学物理学杂志,2001,18(1):18-19. Zhang JT,Wu ZH,Lu XW,et al. Systemic irradiation technology for linear accelerators[J].Chin J Med Phys,2001,18(1):18-19. [13] Pacyna LG,Darby M,Prado K.Use of thermoluminescent dosimetry to verify dose compensation in total body irradiation[J].Med Dosi,1997,22(4):319-324.DOI:10.1016/S0958-3947(97)00107-6. [14] 刘小毛,陈立新,卢杰,等.三维治疗计划系统模拟全身照射的应用研究[J].中国医学物理学杂志,2009,26(6):1474-1476. Liu XM,Chen LX,Lu J,et al. Study on the application of three-dimensional treatment planning system to simulate systemic irradiation[J].Chin J Med Phys,2009,26(6):1474-1476. [15] Bloemen-van Gurp EJ,Mijnheer BJ,Verschueren TA,et al. Total body irradiation,toward optimal individual delivery:dose evaluation with metal oxide field effect transistors,thermoluminescence detectors,and a treatment planning system[J].Int J Radiat Oncol Biol Phys,2007,69(4):1297-1304.DOI:10.1016/j.ijrobp.2007.07.2334. [16] 吴爱东,孙自敏,张红雁,等.全身照射及半导体实时剂量监测技术在造血干细胞移植中应用[J].中华放射肿瘤学杂志,2010,19(1):56-59.DOI:10.3760/cma.j.issn.1004-4221.2010.01.021. Wu AD,Sun ZM,Zang HY,et al. Application of systemic irradiation and semiconductor real-time dose monitoring in hematopoietic stem cell transplantation[J].Chin J Radiat Oncol,2010,19(1):56-59.DOI:10.3760/cma.j.issn.1004-4221.2010.01.021. [17] Bednarz B,Xu X G.Monte Carlo modeling of a 6 and 18 MV Varian Clinac medical accelerator for in-field and out-of-field dose calculations:development and validation[J].Phys Med Biol,2009,54(4):N43-N57.DOI:10.1088/0031-9155/54/4/N01. [18] Bednarz B.Detailed Varian Clinac accelerator modeling for calculating intermediate-and low-level non-target organ doses from radiation treatment[J]. Dissertations& Theses-Gradworks,2008:32-41. [19] Watts RJ.Comparative measurements on a series of accelerators by the same vendor[J].Med Phys,1999,26(12):2581-2585.DOI:10.1118/1.598796. [20] Schneider U,Pedroni E,Lomax A.The calibration of CT Hounsfield units for radiotherapy treatment planning[J].Phys Med Biol,1996(41)111-124. [21] Schneider W,Bortfeld T,Schlegel W.Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions[J].Phys Med Biol,2000,45(2):459-478.
2019, Vol. 28 
