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中华放射肿瘤学杂志
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中华放射肿瘤学杂志  2019, Vol. 28 Issue (1): 65-68    DOI: 10.3760/cma.j.issn.1004-4221.2019.01.014
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三维培养体系下肿瘤细胞放射抵抗与增敏的研究进展
高嘉浓1, 梁珊珊2, 于炜婷3, 王若雨1,2
1大连大学附属中山医院肿瘤科 116001;
2辽宁省乳腺及消化肿瘤分子标志物高通量筛选及靶向药物转化重点实验室,大连 116001;
3大连大学附属中山医院骨科医学研究中心 116001;
Research progress on radioresistance and sensitization of tumor cells in three-dimensional culture system
Gao Jianong1, Liang Shanshan2, Yu Weiting3, Wang Ruoyu1,2
1Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001,China;
2Key Laboratory of High-Throughput Screening or Targeted Drug Transformation of Molecular Markers of Breast and Digestive Tumors in Liaoning Province, Dalian 116001,China;
3Department of Orthopedics Medical Research Center, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001,China;
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摘要  三维细胞培养是一种新型的体外培养方式,该体系能够模拟体内细胞生长的微环境,使细胞表现出更接近于体内的状态与功能。目前,三维培养体系已广泛应用于组织工程和肿瘤细胞生物学等研究领域。放疗是肿瘤治疗的重要手段,肿瘤细胞的放射抵抗是导致治疗失败和复发转移的主要原因。肿瘤细胞在三维培养体系下能够表现出体内肿瘤组织内部细胞的抵抗特性,因此利用三维培养体系对肿瘤细胞放射抵抗作用与机制进行研究,鉴定调控肿瘤放射抵抗的关键因子,是增加放射敏感性和提高放疗效果的关键。这篇文章将对近年来在三维培养体系下,肿瘤细胞放射抵抗和增敏的研究进展做一综述,为相关研究提供参考。
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高嘉浓
梁珊珊
于炜婷
王若雨
关键词 三维培养 肿瘤细胞 放射抵抗 放射增敏 基质材料    
Abstract: Three-dimensional cell culture is a novel type of in vitro culture method. This system can mimic the microenvironment of cell growth in vivo, where cells exhibit similar state and function to that in the in vivo environment. Currently, three-dimensional culture system has been widely applied in tissue engineering and tumor cell biology fields, etc. Radiotherapy is an important treatment of cancer. Radioresistance of tumor cells is the main cause of treatment failure, tumor recurrence and metastasis. Tumor cells can exhibit the resistant characteristics in the three-dimensional culture system, similar to those of tumor cells in vivo. Therefore, three-dimensional culture system can be adopted to investigate the radioresistance and underlying mechanism of tumor cells and identify the key factors regulating the radioresistance of tumor cells, which plays a pivotal role in enhancing the radioresistance and improving the effect of radiotherapy. This article will review recent research progress in the radioresistance and sensitization of tumor cells under three-dimensional culture system, aiming to provide reference for relevant investigations.
Key wordsThree-dimensional culture    Tumor cell    Radioresistance    Radiosensitization    Matrix material   
收稿日期: 2018-07-23     
通讯作者: 于炜婷,Email:yuweiting@dlu.edu.cn,电话:0411-62893509;王若雨,Email:wangruoyu1963@163.com,电话:0411-62893203   
引用本文:   
高嘉浓,梁珊珊,于炜婷等. 三维培养体系下肿瘤细胞放射抵抗与增敏的研究进展[J]. 中华放射肿瘤学杂志, 2019, 28(1): 65-68.
Gao Jianong,Liang Shanshan,Yu Weiting et al. Research progress on radioresistance and sensitization of tumor cells in three-dimensional culture system[J]. Chinese Journal of Radiation Oncology, 2019, 28(1): 65-68.
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