Study of volume resolution of prostate motion target by four-dimensional ultrasound
Lu Zhengda1, Bi Hui2, Li Chunying2, He Mu2, Gao Liugang2, Sun Jiawei2, Xie Kai2, Lin Tao2, Sui Jianfeng2, Ni Xinye2
1Academy of Biomedical Engineering and Information, Nanjing Medical University, Nanjing 210000, China; 2Department of Radiotherapy, Nanjing Medical University Affiliated Second People's Hospital of Changzhou/Center for Medical Physics Nanjing Medical University/Key Laboratory of Medical Physics, Changzhou 213000, China
Abstract：Objective To explore the volume resolution of prostate motion target by four-dimensional (4D) ultrasound. Methods The prostate ultrasound model was selected, and the group comparison study was conducted using 4D ultrasound to outline the prostate target under different motion amplitudes (A) and motion period (T). The simulated A value was set as 0.5 mm, 1 mm, 2 mm, 3 mm, 4 mm, and 5 mm, respectively. The T value was set as 1s, 2s, 3s, and 4s, respectively. The volume of the target of the model prostate was calculated, and the static ultrasound image of the target was used as the control group to analyze the difference between two groups. Results When the model was still, the size of the target of ultrasound was consistent with that of CT scan (P>0.05). When the A values were 0.5 mm and 1 mm, there was no statistical difference between the volume in period 1-4s and the volume in the target at rest (all P>0.05). When the A values were 2 mm and 3 mm, and the T values were 1s, 2s and 3s there was statistical difference between the volume of target and that of of static ultrasonic target (all P<0.05). When the A value was 2 mm and the T value was 4s, there was no statistical difference between the target volume and the static target volume (P=0.710). The range within the group was 6.7cm3, and the standard deviation was 1.15cm3. When the A value was 3 mm and the T value was 4s, the volume repeatability of the target was poor, and the range within the group was 14.4cm3;when the A values were 4 mm and 5 mm, and the T values were 1-4s, the range within the group was 3.27-17.63cm3 and 6.51-21.02cm3, respectively. The volume repeatability of the target under each period was extremely poor, which could not meet the clinical requirements. Conclusion 4D ultrasound can provide reliable reference data for patients' target delineation within 1-4s of motion cycle and within 1 mm of motion amplitude, which exerts on effect upon the original position of probe.
Lu Zhengda,Bi Hui,Li Chunying et al. Study of volume resolution of prostate motion target by four-dimensional ultrasound[J]. Chinese Journal of Radiation Oncology, 2021, 30(12): 1292-1296.
2021, Vol. 30 
