Abstract：Objective To analyze the invasion characteristics and prognostic factors of patients with Masaoka-Koga stage Ⅲ thymoma. Methods The tumor invasion characteristics of 179 patients who were diagnosed with Masaoka-Koga stage Ⅲ thymoma and treated in Affiliated Cancer Hospital of Zhengzhou University from January 2000 to June 2018 were analyzed retrospectively. According to the treatment methods, all patients were divided into the radical operation group (n=94), palliative operation group (n=39) and simple biopsy group (n=46). The χ2 test was used to compare the classified variables, Kaplan-Meier method was utilized to calculate the cumulative survival rate, log-rank method was used for group comparison and univariate analysis, and Cox’s regression model was used for multivariate analysis. Results Mediastinal pleural invasion (86.0%) was the most common site, followed by pericardium (50.8%), great vessel (40.8%) and lung (36.3%). The proportion of macrovascular invasion in the radical operation group was 14.9%, significantly lower than 79.5% and 60.9% in the palliative surgery group and biopsy group (both P<0.001). Multivariate analysis showed that the nature of operation (P<0.001), age (P=0.011), radiotherapy (P=0.020) were the independent factors affecting overall survival (OS), while nature of operation (P<0.001), age (P=0.004), radiotherapy (P=0.020), number of invasive organs (P=0.023) and pathological type (P=0.016) were the independent factors affecting progress-free survival (PFS). Conclusions For patients with Masaoka-Koga stage Ⅲ thymoma, mediastinal pleura is the most common site of invasion, pericardium, lung and great vessels are also commonly invaded. The invasion of mediastinal pleura, pericardium and lung exerts slight effect on surgical resectability, whereas great vessel involvement can significantly affect surgical resectability. OS and PFS in patients undergoing radical resection are significantly better than those in patients treated with palliative resection and biopsy. Radical resection is the most important factor affecting prognosis.
Fan Chengcheng,Ge Hong,Zhang Yougai et al. Analysis of invasion characteristics and prognostic factors of patients with Masaoka-Koga stage Ⅲ thymoma[J]. Chinese Journal of Radiation Oncology, 2021, 30(1): 29-33.
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