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热疗与肿瘤细胞乏氧微环境下能量代谢的研究现状
石凡1, 孙巧珍1, 周学筱1, 徐婷2, 王升志2
1青岛大学口腔医学院 266003; 2青岛大学附属烟台毓璜顶医院口腔颌面外科,烟台 266400
Research status of hyperthermia and energy metabolism of tumor cells in hypoxic microenvironment
Shi Fan1, Sun Qiaozhen1, Zhou Xuexiao1, Xu Ting2, Wang Shengzhi2
1School of Stomatology, Qingdao University, Qingdao 266003, China; 2Department of Oral and Maxillofacial Surgery, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai 266400, China
Abstract：Metabolic reprogramming is a malignancy hallmark, which refers to the ability of cancer cells to alter metabolic and nutrient acquisition modes in order to support the energy demands for accomplishing the rapid growth, dissemination, metastasis and obtain the “building blocks” needed to maintain cell division. When solid tumors are exposed to low pH, low oxygen and tumor microenvironment with nutrient deficiencies,the hypoxia-inducible factor-1 can be activated, which mediates the remodeling of metabolic patterns in tumor cells, namely, energy is obtained by circulating intracellular components (removing substrates such as proteins and lipid) or by utilizing adaptive metabolic reprogramming (such as glycolysis, autophagy and lipid metabolism, etc.). As a treatment scheme based on local heating of tumors, hyperthermia has a variety of anticancer mechanisms and can be used in combination with radiotherapy, chemotherapy and biological immune therapy. In this review, we briefly discussed the metabolic remodeling model mediated by hypoxia-inducible factor 1 in a hypoxia microenvironment, described the possible regulatory mechanism of hyperthermia on hypoxia-inducible factor-1 and prospected the application of hyperthermia in oral and maxillofacial tumors.
Shi Fan,Sun Qiaozhen,Zhou Xuexiao et al. Research status of hyperthermia and energy metabolism of tumor cells in hypoxic microenvironment[J]. Chinese Journal of Radiation Oncology, 2021, 30(1): 102-106.
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