1Department of Radiation Oncology,Second Affiliated Hospital of Soochow University,Suzhou 215004,China; 2Department of Radiation Oncology,Affiliated Taixing People's Hospital of Yangzhou University,Taixing 225400,China; 3Department of Radiation Oncology,The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou 215001,China
Abstract：Objective To evaluate the role of prognostic nutritional index (PNI) in the radiotherapy for elderly patients with esophageal squamous cell carcinoma. Methods Clinical data of 108 elderly patients (aged>65 years) with esophageal squamous cell carcinoma who underwent radical radiotherapy were retrospectively analyzed. The PNI value of each patient was calculated, and the optimal cutoff value of PNI before treatment was determined by establishing the receiver operating characteristic curve (ROC curve). All patients were divided into the low and high PNI value groups. The overall survival rate was calculated by Kaplan-Meier method. Log-rank test, univariate and Cox’s multivariate prognosis analyses were performed. Results The ROC curve demonstrated that the optimal cutoff value of PNI was 50.1(n=52 in high PNI group and n=56 in low PNI group). Age, gender and treatment did not significantly differ between two groups, whereas the TNM staging significantly differed (P=0.022). The effective rate of radiotherapy in the high PNI group was 96%, significantly higher than 73% in the low PNI group (P=0.001). In the high PNI group, the 1-,2-,and 3-year overall survival rates were 94%,69%,and 62%,significantly higher compared with 70%, 32% and 27% in the low PNI group (all P<0.001). Univariate analysis showed that PNI,T staging, N staging and TNM staging were significantly correlated the overall survival of patients (all P<0.01).Cox’s multivariate analysis revealed that N staging (RR=1.94,95%CI=1.29-2.94,P=0.002) and PNI (RR=0.83,95%CI=0.77-0.90,P<0.001) were independent risk factors affecting overall survival. Conclusions PNI before treatment has a good correlation with the prognosis and radiotherapy efficacy of patients, which can be used as a pivotal index to predict the clinical benefit of radiotherapy for elderly patients with esophageal squamous cell carcinoma.
Xu Yingying,Guo Xinwei,Ji Shengjun et al. Predictive value of prognostic nutritional index for radiotherapy and prognosis of elderly patients with esophageal squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(9): 669-672.
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2019, Vol. 28 
