Relationship between factors of gross tumor volume and locoregional failure of radical intensity-modulated radiation therapy for esophageal carcinoma
Zeng Jing1,2, Pang Qingsong1, Zhang Wencheng1, Guan Yong1, Qian Dong1, Wang Ping1, Qu Pengpeng2, Zhao Lujun1, Wang Jun1, Wang Daquan1, Shi Xiangyu1, Liu Xiaojie1
1Department of Radiobiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Centre of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin′sClinical Medical Research Center for Cancer,Tianjin, Tianjin 300060, China; 2Department of Gynecology, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin 300100, China
Abstract：Objective Investigate the relationship between gross tumor volume (GTV)-related factors includingGTV-T volume,the maximum thickness of the esophageal lesion plane and GTV-T volume/length(GTV-T volume divided by the length of the lesion calculated by the number of GTV-T layers) and the locoregional failure of radical intensity-modulated radiation therapy (IMRT) for esophageal carcinoma. Methods A total of 133 patients with esophageal cancer undergoing radical IMRT were enrolled. The factors related to GTV-T including GTV-T volume, the maximum thickness of the esophageal lesions, GTV-T volume/length were calculated. The relationship between GTV-T related factors and local recurrence of tumors was retrospectively analyzed. Results There was positively linear association between the locoregional failure rate of GTV-T and the volume of GTV-T. The volume of GTV-T tumor was 36 cm3, the maximum wall thickness was 2.5 cm, and the GTV-T volume/length was calculated as 5.3 cm2. These critical values could be utilized to predict the risk of locoregional failure of IMRT for esophageal carcinoma. Conclusions The GTV-T factors can be adopted to predict the local control and the risk of locoregional failure of radical IMRT for esophageal carcinoma to certain extent.
Zeng Jing,Pang Qingsong,Zhang Wencheng et al. Relationship between factors of gross tumor volume and locoregional failure of radical intensity-modulated radiation therapy for esophageal carcinoma[J]. Chinese Journal of Radiation Oncology, 2019, 28(2): 85-89.
[1] Cooper JS,Guo MD,Herskovic A,et al. Chemoradiotherapy of locally advanced esophageal cancer:long-term follow-upofa prospective randomized trial (RTOG 85-01)[J].JAMA,1999,281(17):1623-1627.DOI:10.1001/jama.281.17.1623. [2] Kachnic LA,Winter K,Wasserman T,et al. Longitudinal quality-of-life analysis of RTOG 94-05(Int 0123):a phase Ⅲ trial of definitive chemoradiotherapy for esophageal cancer[J]. Gastrointest Cancer Res,2011,4(2):45-52. [3] Lin SH,Wang L,Myles B,et al. Propensity score-based comparison of long-term outcomes with 3-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy for esophageal cancer[J]. Int J Radiat Oncol Biol Phys, 2012,84(5):1078-85.DOI:10.1016/j.ijrobp.2012.02.015. [4] Stahl M, Stuschke M, Lehmann N, et al. Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus.[J]. Journal of Clinical Oncology, 2005, 23(10):2310-2317.DOI:10.1200/JCO.2005.00.034 [5] Bedenne L,Michel P,Bouché O,et al. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus:FFCD9102[J].J Clin Oncol,2007,25(10):1160-1168.DOI:10.1200/JCO.2005.04.7118. [6] Ajani JA,Correa AM,Hofstetter WL,et al. Clinical parameters model forpredicting pathologic complete response following preoperative chemoradiation in patients with esophageal cancer[J].Ann Oncol,2012,23(10):2638-2642. DOI:10.1093/annonc/mds210. [7] Lin SH,Wang J,Allen PK,et al. A nomogram that predicts pathologic complete response to neoadjuvant chemoradiational so predicts survival outcomes after definitive chemoradiation for esophageal cancer[J]. J Gastrointest Oncol,2015,6(1):45-52.DOI:10.3978/j.issn.2078-6891.2014.054. [8] Fu MF,Wen LT,Herng CC,et al. Quality of life as a survival predictor for esophageal squamous cell carcinoma treated with radiotherapy[J].Int J Radiat Oncol Biol Phys,2004,58(5):1394-1404.DOI:10.1016/S0360-3016(03)02270-3. [9] 祝淑钗,李任,王玉祥,等.500例中晚期食管癌单纯放疗的多因素分析[J].中华放射肿瘤学杂志,2005,14(4):253-258. Zhu SC,Li R,Wang YX,et al. Multi-factor analysis of simple radiotherapy for advanced esophageal carcinoma in 500 cases[J].Chin J Radiat Oncol,2005,14(4):253-258. [10] Welsh J,Settle SH,Amini A,et al. Failure patterns in patients with esophageal cancer treated with definitive chemoradiation[J]. Cancer,2012,118(10):2632-40.DOI:10.1002/cncr.26586. [11] Welsh J,Riley B,Palmera M,et al. Intensity modulated proton therapy allows dose escalation and normal-tissue sparing in locally advanced distal esophageal tumors[J].Int J Radiat Oncol Biol Phys,2010,78(3):S808.DOI:10.1016/j.ijrobp.2010.07.1872. [12] Eisenhauer EA,Therasse P,Bogaerts J,et al. New response evaluation criteria in solid tumours:revised RECIST guideline (version 1.1)[J]. Eur J Cancer,2009,45(2):228-247.DOI:10.1016/j.ejca.2008.10.026. [13] IIzuka T,Isono K,Kakegawa T,et al. Parameters linked to ten-year survival in Japan of resected esophageal carcinoma[J].Chest,1989,96(5):1005-1011.DOI:10.1378/chest.96.5.1005. [14] Sobin LH,Hermanek P,Hutter RV,et al. TNM classification of malignant tumors. Acomparison between the new (1987) and the old editions[J].Cancer,1988,61(11):2310-2314.DOI:10.1002/1097-0142(19880601)61:11<2310::aid-cncr2820611127>3.0.co [15] Edge SB,Byrd DR,Compton CC,et al. American joint committee on cancer (AJCC) cancer staging manual[M].7th ed. Chicago:Springer,2010:p31-35. [16] Rice TW,Rusch VW,Blackstone EH.2009 AJCC/UICC staging of esophageal cancer[A]//Shields TW,Locicero J,Reed CE,Feins RH.General thoracic surgery[M].7th ed. Netherlands:Wolters Kluwer,2009:2013-2015. [17] Chen CZ,Chen JZ,Li DR,et al. Long-term outcomes and prognostic factors for patients with esophageal cancer followingradiotherapy[J]. World J Gastroenterol,2013,19(10):1639-1644.DOI:10.3748/wjg.v19.i10.1639. [18] Twine CP,Roberts SA,Rawlinson CE,et al. Prognostic significance of the endoscopic ultrasound defined lymph node metastasis count in esophageal cancer[J].Dis Esophagus,2010,23(8):652-659.DOI:10.1111/j.1442-2050.2010.01072.x. [19] Natsugoe S,Yoshinaka H,Shimada M,et al. Number of lymph node metastases determined by presurgical ultrasound and endoscopic ultrasound is related to prognosis in patients with esophageal carcinoma[J].Ann Surg,2001,234(3):613-618. DOI:10.1097/00000658-200111000-00005. [20] Gaur P,Sepesi B,Hofstetter WL,et al. Endoscopic esophageal tumor length:a prognostic factor for patients with esophageal cancer[J].Cancer,2011,117(1):63-69.DOI:10.1002/cncr.25373. [21] 王澜,韩春,张辛,王军,等.食管癌适形放疗预后因素的Cox模型分析[J].中华肿瘤防治杂志,2009,16(1):58-61. Wang L,Han C,Wang J,et al. Cox model analysis of prognostic factors in conformal radiotherapy of esophageal carcinoma[J]. Chin J Cancer Prevent Treat,2009,16(1):58-61.
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