Prognostic value of anemia in patients with extranodal nasal-type NK/T cell lymphoma:A multi-center study from CLROG
Fang Hui, Zhu Suyu, Xu Liming, Wang Peiguo, Wu Tao, Qian Liting, Zhang Fuquan, Hou Xiaorong, Qi Shunan, Yang Yong, Jin Jing, Zhang Yujing, Zhu Yuan, Cao Jianzhong, Lan Shengmin, Wu Junxin, Li Yexiong
Department of Radiation Oncology,National Cancer Center/ Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China (Fang H,Qi SN,Yang Y,Jin J,Li YX) Department of Radiation Oncology,Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine,Changsha 410006,China (Zhu SY) Department of Radiation Oncology,Cancer Hospital,Tianjin Medical University,Tianjin 300070,China (Xu LM,Wang PG) Department of Radiation Oncology,Guizhou Cancer Hospital,Guiyang 550000,China (Wu T) Department of Radiation Oncology,Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,China (Qian LT) Department of Radiation Oncology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100730,China (Zhang FQ,Hou XR) Department of Radiation Oncology,Sun Yat-sen University Cancer Center,Guangzhou 510060,China (Zhang YJ) Department of Radiation Oncology,Zhejiang Cancer Hospital,Hangzhou 310022.China (Zhu Y) Department of Radiation Oncology,Shanxi Cancer Hospital,Taiyuan 030013,China (Cao JZ,Lan SM) Department of Radiation Oncology,Fujian Provincial Cancer Hospital,Fuzhou 350014,China (Wu JX)
Abstract：Objective To evaluate the prognostic value of anemia in patients diagnosed with extranodal nasal-type natural killer (NK)/T cell lymphoma (NKTCL). Methods Clinical data of 1225 NKTCL patients receiving the first course of treatment from 10 medical institutions in China were retrospectively analyzed. According to the diagnostic criteria in China, anemia was defined as the hemoglobin (Hb) level< 120 g/L for the male and< 110 g/L for the female from the sea-level area. The severity of anemia was classified into the extremely severe anemia (Hb ≤ 30 g/L), severe anemia (31-60 g/L), moderate anemia (61-90 g/L) and mild anemia (>90 g/L). Results Among 1225 patients, 199(16.2%) were complicated with anemia, who had more adverse prognostic factors compared with their counterparts without anemia. Among NKTCL patients with anemia, the proportion of patients with stage Ⅱ-IV, a median age> anemia, Eastern Cooperative Oncology Group (ECOG) score of 2-4 and NK/T-cell lymphoma prognostic index (NKTCLPI) ≥ 2 was relatively high. Patients with anemia obtained worse clinical prognosis than those without anemia. The 5-year overall survival (OS) and progression-free survival (PFS) in NKTCL patients with anemia were calculated as 49.4% and 35.4%, significantly lower compared with 63.3% and 56.0% in their counterparts without anemia (both P<0.01). Single factor analysis demonstrated that anemia, age, ECOG score, group B symptom, lactate dehydrogenase, primary tumor site, primary tumor invasion and staging were the prognostic factors of OS and PFS. Multivariate analysis revealed that anemia was still the independent prognostic factor. Conclusions Anemia is not common in patients with NKTCL and these patients obtain poor clinical prognosis. Anemia is an independent prognostic factor for patients with NKTCL.
Fang Hui,Zhu Suyu,Xu Liming et al. Prognostic value of anemia in patients with extranodal nasal-type NK/T cell lymphoma:A multi-center study from CLROG[J]. Chinese Journal of Radiation Oncology, 2018, 27(2): 155-160.
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