Influence of enteral nutrition on nutritional status,treatment toxicities,and short-term outcomes in esophageal carcinoma patients treated with concurrent chemoradiotherapy:a prospective,multicenter,randomized controlled study (NCT 02399306)
Lyu Jiahua, Li Tao, Zhu Guangying, Li Jie, Zhao Ren, Zhu Shuchai, Wang Jianhua, Xing Ligang, Yang Daoke, Xie Conghua, Shen Liangfang, Zhang Hailin, Shi Anhui, Wang Jing, Pan Wenyan, Li Fang, Wang Qifeng, Lang Jinyi, Shi Hanping
Sichuan Cancer hospital institute/Sichuan Cancer Center/School of Medicine,University of Electronic Science and Technology of China,Chengdu,610041,China (Lyu JH,Li T,Zhang HL,Li F,Wang QF,Lang JY); Beijing Cancer Hospital,Beijing 100142,China (Zhu GY (Present unit:China-Japan Friendship Hospital),Shi AH); Shanxi Cancer Hospital,Taiyuan,030013,China (Li J,Wang J); General Hospital of Ningxia Medical University,Yinchuan 750004,China (Zhao R,Pan WY); Fourth Hospital of Hebei Medical University,Shijiazhuang 050035,China (Zhu SC); Henan Cancer Hospital,Zhengzhou 450008,China (Wang JH); Shandong Cancer Hospital,Jinan,250117,China (Xing LG); First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China (Yang DK); Zhongnan Hospital of Wuhan University,Wuhan,430071,China (Xie CH); Xiangya Hospital of Centre-south University,Changsha 410008,China (Shen LF); Beijing Century Altar Hospital Affiliated to the Capital Medical University,Beijing 100038,China (Shi HP)
Abstract：Objective To investigate the influence of enteral nutrition on body weight,nutritional status,treatment toxicities,and short-term outcomes in esophageal carcinoma patients treated with concurrent chemoradiotherapy (CCRT). Methods Eligible esophageal carcinoma patients were randomly assigned (2:1) to receive either CCRT combined with enteral nutrition (study group) or CCRT alone (control group).The primary endpoint was changes in the body weight during and after radiotherapy. The secondary endpoints were nutrition-related hematological parameters,the toxicities of chemoradiotherapy,the completion rate of treatment,and short-term outcomes. The differences was using χ2 or t-test. Results Between September 2014 and June 2017,203 patients were included in the study,consisting of 139 patients in the study group and 64 patients in the control group. Compared with the control group,the study group had significantly less body weight loss during and after radiotherapy (P<0.05) and significantly less decreases in serum albumin and hemoglobin (P<0.05),but there was no significant difference in the reduction in total lymphocyte count between the two groups (P>0.05).The study group had significantly lower incidence rates of grade ≥3 myelosuppression and infection and a significantly higher completion rate of chemoradiotherapy compared with the control group (P<0.05).The incidence of radiation pneumonitis and esophagitis showed no significant difference between the two groups (P>0.05).The study group had an insignificantly higher Objective response rate than the control group (P>0.05). Conclusions For esophageal carcinoma patients treated with CCRT,enteral nutrition can reduce body weight loss during and after radiotherapy,improve nutritional status and treatment tolerance,and reduce toxicities.
Lyu Jiahua,Li Tao,Zhu Guangying et al. Influence of enteral nutrition on nutritional status,treatment toxicities,and short-term outcomes in esophageal carcinoma patients treated with concurrent chemoradiotherapy:a prospective,multicenter,randomized controlled study (NCT 02399306)[J]. Chinese Journal of Radiation Oncology, 2018, 27(1): 44-48.
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2018, Vol. 27 
