IMRT中OAR和靶区相交体积与其吸收剂量间关系研究

doi:10.3760/cma.j.issn.1004-4221.2017.02.014

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摘要目的探讨IMRT中OAR与靶区相交体积(V_overlap)和平均剂量(D_mOAR)之间的相关关系。方法随机选取本院接受鼻咽癌IMRT的患者与宫颈癌根治性IMRT的患者各50例,以此为模板分析IMRT中V_overlap与其D_mOAR之间的关系,并利用matlab软件拟合出不同OAR上述二者之间的相关公式。结果鼻咽癌与宫颈癌患者OAR和靶区相交体积因人而异,V_overlap与其本身体积(V_OAR)的比值与D_mOAR和处方剂量(D_p)比值之间存在着显著正相关性(P均=0.01),并得到出二者之间相关公式。结论 IMRT过程中患者靶区大小各异,不同分期和OAR充盈程度及大小不一等因素也会导致不同V_overlap/V_OAR。在制作放疗计划前根据不同OAR拟合出相关公式,在给定处方条件下通过V_overlap/V_OAR提前计算出各自D_mOAR,作为计划验收标准,从而减少放疗计划优化过程中主观因素造成影响。

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	庞皓文
	孙小杨
	杨波
	石翔翔
	唐涛
	吴敬波

关键词 ：放射疗法, 计算机辅助, 危及器官, 相关性

Abstract：Objective To explore the relationship between the overlap volume of organ at risk (OAR) and target (V_overlap) and the mean dose to OAR (D_mOAR) in intensity-modulated radiotherapy (IMRT). Methods Fifty randomly selected patients undergoing IMRT for nasopharyngeal carcinoma (NPC) and an equal number of patients undergoing radical IMRT for cervical cancer in our hospital were enrolled as subjects. The relationship between V_overlap and D_mOAR in IMRT was analyzed. The Matlab software was used to generate function to fit the relationship between V_overlap and D_mOAR for different OARs. Results The V_overlap varied among patients with NPC or cervical cancer. The ratio of V_overlap to the volume of OAR (V_OAR) was positively correlated with the ratio of D_mOAR to the prescribed dose (D_p)(all P=0.01). A function was generated to fit the correlation between V_overlap/V_OAR ratio and D_mOAR/D_p ratio. Conclusions In IMRT, patients have different V_overlap/V_OAR ratios due to varied target volume, disease stages, OAR filling status, and OAR volume. As criteria for plan verification, a specific D_mOAR value for each OAR should be calculated before radiotherapy planning based on the corresponding correlation function and the V_overlap/V_OAR ratio with a fixed dose prescription. It can be used to reduce the subjective influence on the optimization of radiotherapy planning.

Key words： Radiotherapy Computer-assisted Organs at risk Correlationship

收稿日期: 2015-12-14

通讯作者: 孙小扬,Email:sunxy0611@126.com

引用本文:

庞皓文,孙小杨,杨波等. IMRT中OAR和靶区相交体积与其吸收剂量间关系研究[J]. 中华放射肿瘤学杂志, 2017, 26(2): 187-191.

Pang Haowen,Sun Xiaoyang,Yang Bo et al. Relationship between the overlap volume of organ at risk and target and the dose to organ at risk in intensity-modulated radiotherapy[J]. Chinese Journal of Radiation Oncology, 2017, 26(2): 187-191.

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