Recent advances of gold nanoparticles for cancer radiotherapy
Yang Ruijie,Xie Yaoqin,Wang Junjie
Department of Radiation Oncology,Third Hospital of Peking University,Beijing 100083,China(Yang RJ,Wang JJ);Biomedical and health Research ,Schenzhen Institute of Advanced Technology,Chinese Academy of Sciences (Xie YQ)Wang Junjie,Email:junjiewang47@yahoo.com
Abstract：Based on a review of currently published 40 papers (20 published in recent 5 years, 20 published in recent 10 years) on gold nanoparticles for cancer radiotherapy, the general characteristics, theoretical studies, in vitro experiment, in vivo experiment,and the clinical prospects of targeted radiotherapy with gold nanoparticles were reviewed. Three key aspects guarantee further investigation for the full understanding of the radiosensitization effect of gold nanoparticles:the cellular localization and tissue distribution of nanoparticles and influential factors;the micro dose enhancement effect of gold nanoparticles, and the molecular biological mechanism. More cross disciplinary collaboration, research, development and translation are needed before gold nanoparticles are put into clinical trials.
Yang Ruijie,Xie Yaoqin,Wang Junjie. Recent advances of gold nanoparticles for cancer radiotherapy[J]. Chinese Journal of Radiation Oncology, 2016, 25(2): 190-193.
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