Abstract：Objective To evaluate the clinical features, treatment outcome, and prognostic factors in patients with primary Waldeyer’s ring diffuse large B-cell lymphoma (WR-DLBCL). Methods This study included 200 patients with a confirmed diagnosis of primary WR-DLBCL admitted to our hospital from 2000 to 2013, who consisted of 50 stage I patients, 125 stage II patients, and 25 stage III-IV patients. Most patients received 4-6 cycles of CHOP or CHOP-based chemotherapy with or without involved field radiotherapy (Waldeyer′s ring+cervical lymph node region). Results The 5-year sample size was 71. The 5-year overall survival (OS), progression-free survival (PFS), and locoregional control (LRC) rates for the whole group were 78%, 72%, and 87%, respectively. In the 175 early stage patients, chemoradiotherapy resulted in significantly higher OS, PFS, and LRC than chemotherapy alone (86% vs. 70%, P=0.001;84% vs. 58%, P=0.000;97% vs. 66%, P=0.000).Univariate analysis showed that age, tumor size, stage, lactate dehydrogenase level, and International Prognostic Index were prognostic factors for OS, PFS, and LRC (P=0.000-0.036), while the prognostic factors for PFS also included Eastern Cooperative Oncology Group score and cervical nodal involvement (P=0.018). Multivariate analysis showed that age and stage were prognostic factors for OS and LRC (P=0.003-0.022), and age was the prognostic factor for PFS (P=0.000). Conclusions WR-DLBCL has distinct clinical features and favorable prognoses. For early stage patients, combined-modality therapy results in significantly higher OS, PFS, and LRC.
Xu Yonggang,Li Yexiong,Wang Weihu et al. Clinical outcome and prognosis of Waldeyer’s ring diffuse large B-cell lymphoma:an analysis of 200 patients[J]. Chinese Journal of Radiation Oncology, 2015, 24(4): 382-386.
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2015, Vol. 24 
