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宫颈癌九野均分与角度优化IMRT计划剂量学比较
庞廷田, 杨波, 邱杰, 张福泉
100730 北京协和医学院 中国医学科学院北京协和医院放疗科
Dosimetric comparison of Cervix uteri irradiation with 9 equal spaced fields IMRT and beam angle optimized IMRT
Pang Tingtian, yang Bo,Zhang Fu-quan,Qiu Jie
Department of Radiotherapy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Abstract：Objective To study the dosimetry characteristics of 9 equal spaced fields and 9 fields with beam angle optimization (BAO) process for cervix uteri. Methods 12 cervix uteri cancer patients CT Images were transferred into Eclipse planning system. Each patient, the 9 equal spaced fields and 9 fields by BAO process were IMRT plan designed with the same CT image. Make a evaluation of dose distribution for target volume and OARs, and paired t test for them. Results Comparing to 9 equal spaced fields IMRT plan, the quality of 9 fields IMRT plan with BAO process the the PTV V95% was 99.31% vs 99.42%,P=0.020, at the same time V105%,V110%,Dmax,Dmean got 60.54% vs 47.92%,P=0.013;7.14% vs 0.37%,P=0.000;56.62 Gy vs 55.47 Gy,P=0.000;53.29 Gy vs 52.72 Gy,P=0.000, the CI and HI was 0.85 vs 0.89,P=0.000;0.10 vs 0.13,P=0.000.For organs at risk, bladder V40 was increased by 4.7%(P=0.013);the D40 of rectum was 0.5 Gy higher (P=0.004);the small bowel′s DVH showed that V40 and Dmax increased by 0.6%(P=0.015) and 1.4 Gy (P=0.000), Dmean of bone marrow were raised separately by 1.3 Gy (P=0.000),the spinal cord′s dose D0.1 cm3 was also increased by 2.0 Gy (P=0.000). Conclusion The quality of 9 equal spaced fields IMRT plan will be better than those achieved by BAO process optimized plans.
Pang Tingtian,yang Bo,Zhang Fu-quan et al. Dosimetric comparison of Cervix uteri irradiation with 9 equal spaced fields IMRT and beam angle optimized IMRT[J]. Chinese Journal of Radiation Oncology, 2014, 23(3): 262-264.
[1] Mundt AJ, Lujan AE, Rotmensch J,et al. Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies[J].Int J Radiat Oncol Biol Phys,2002,52:1330-1337. [2] Alber M, Nusslin F. Optimization of intensity modulated radiotherapy under constraints for static and dynamic MLC delivery[J].Phys Med Biol,2001,46:3229-3239. [3] Pugachev A, Xing L. Incorporating prior knowledge into beam orientation optimization in IMRT[J]. Int J Radiat Oncol Biol Phys,2002,54:1565-1574. [4] Bortfeld T. Optimized planning using physical objectives and constraints[J]. Semin Radiat Oncol,1999,9:20-34. [5] Wang C, Dai J, Hu Y. Optimization of beam orientations and beam weights for conformal radiotherapy using mixed integer programming[J]. Phys Med Biol,2003,48:4065-4076. [6] Das S, Cullip T, Tracton G,et al. Beam orientation selection for intensity-modulated radiation therapy based on target equivalent uniform dose maximization[J]. Int J Radiat Oncol Biol Phys,2003,55:215-224. [7] Liu HH, Jauregui M, Zhang X, et al. Beam angle optimization and reduction for intensity-modulated radiation therapy of nonsmall-cell lung cancers[J]. Int J Radiat Oncol Biol Phys,2006,65:561-572. [8] Van Esch A, Tillikainen L, Pyykkonen J, et al. Testing of the analytical anisotropic algorithm for photon dose calculation[J]. Med Phys,2006,33:4130-4148. [9] Cahlon O, Hunt M, Zelefsky MJ. Intensity-modulated radiation therapy:supportive data for prostate cancer[J].Semin Radiat Oncol,2008,18:48-57. [10] Paddick I. A simple scoring ratio to index the conformity of radiosurgical treatment plans[J]. J Neurosurg,2000,93(Suppl 3):219-222. [11] Shiv P, Srivastava I, Ndra J, et al. Dosimetric comparison of manual and beam angle optimization of gantry angles in IMRT[J].Med Dosim,2011,36:3313-316. [12] Zhang PP, Happersett L, Yang YL, et al. Optimization of collimator trajectory in volumetric modulated arc therapy:development and evaluation for paraspinal SBRT[J]. Int J Radiat Oncol Biol Phys,201,77:2591-2599.
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