Gross tumor volume delineation with combination of non-contrast/contrast CT and FDG PET in pancreatic cancer
GONG Lin-lin*, LIU Ning-bo, ZHU Lei, YANG Cheng-wen, ZHAO Lu-jun, LI Rui-jian, WANG Ping
*Department of Radiotherapy, Cancer Institute and Hospital of Tianjin Medical University;Tianjin Key laboratory of Tumor Research and Control;Tianjin 300060, China Corresponding author:WANG Ping,Email:wangping.9999@yahoo.com.cn
Abstract：Objective To investigate the application of non-contrast and contrast-enhanced 18FDG PET/CT in the delineation of gross tumor volume (GTV) of pancreatic cancer. Methods Between Jan.2008 and Dec.2009, twenty-one patients with unresectable locally advanced pancreatic cancer or recurrent pancreatic cancer after surgery in our hospital had both non-contrast CT and PET images acquired at the same body position. Among the whole group, eleven patients also had contrast CT images. The image data sets were transferred to the treatment planning workstation for registration. Then gross tumor volumes (GTV) were delineated independently using the information of PET images, contrast/non-contrast CT scan and contrast/non-contrast PET-CT fusion images. The differences of mean volume in these different sets of GTV were analyzed. Results For the whole group, the mean volume of non-contrast GTVCT, GTVPET, non-contrast GTVPET-CT were 76.9 cm3, 47.0 cm3 and 44.5 cm3, respectively. The mean volume of non-contrast GTVPET-CT was significantly smaller than non-contrast GTVCT(z=－3.91, P=0.000). For the eleven patients with contrast CT, the mean volume of contrast GTVCT, GTVPET, contrast GTVPET-CT were 64.1 cm3, 45.1 cm3 and 49.3 cm3,respectively. The mean volume of contrast GTVPET-CT was significantly smaller than contrast GTVCT(z=－2.13, P=0.033). No significant differences were found between contrast PET-CT and non-contrast PET-CT (z=－0.80,P=0.424). Conclusions Co-registration of PET and contrast/non-contrast CT information in pancreatic cancer may improve the accuracy of GTV delineation, and possibly reduce the adverse effect of irradiation.
GONG Lin-lin*,LIU Ning-bo,ZHU Lei et al. Gross tumor volume delineation with combination of non-contrast/contrast CT and FDG PET in pancreatic cancer[J]. Chinese Journal of Radiation Oncology, 2012, 21(3): 255-257.
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2012, Vol. 21 
