Abstract: 【Purpose/significance】The topic clustering method is used to reveal the research hot spots of domestic block-chain, so as to provide reference for the research work of block-chain in the Area of Library and Information.【Method/process】The article takes papers on the subject of block-chain in library and information recruited by the database CNKI as the data source，extracted 470 key‐words，and then using Jaccard coefficient the similarity of literature to formed 10 Topic clusters, using information gain method calcu‐lated the contribution of each key word in topic clustering. Through the top 10 core keywords, this paper expounds the main research contents of the research papers in each topic clustering, and analyzes the future development trend of block-chain in the field of li‐brary and information through the annual document trend under topic clustering【. Result/conclusion】This paper proposes 10 topic clus‐ters of block-chain technology, smart library, resource construction, information service, reading promotion, privacy protection, borrow‐ing service, scientific data, copyright protection and information analysis, summarizes them into a research framework including basic layer, technology layer, application layer and extension layer, and analyzes that the future research trend will focus more on informa‐tion analysis, smart library, reading promotion, scientific data, copyright protection and privacy protection【. Innovation/limitation】More perspectives can be adopted for the analysis of research topics, such as knowledge graph.