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The effect of microwave radiation on the permeability change of blood brain barrier
Wu Zhibing, Wu Kan, Wu Yajun, Ma Shenglin
Center of Hyperthermia Oncology,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China (Wu ZB,Ma SL); Department of Radiation Oncology,Hangzhou Cancer Hospital,Hangzhou 310002,China (Wu ZB,Wu K); Key Laboratory of Molecular Oncology of Chinese Medicine and Western Medicine,Hangzhou 310006,China (Wu ZB,Ma SL); Zhejiang Chinese Medical University,Hangzhou 310053,China (Wu YJ)
Abstract Microwave radiation plays an important role in the diagnosis and treatment of malignant tumors. Whether microwave radiation can improve the effect of chemotherapy on intracranial carcinoma through improving the permeability of blood brain barrier is a hot topic at present. Blood-brain barrier permeability can be increased by microwave radiation though thermal effect and non thermal effect,and the mechanism may be related to the regulation of vascular endothelial growth factor,Occludin,aquaporin 4 and adhesion molecule-1.However,there are still questions on the physical parameters,include temperature,microwave frequency,specific absorption rate and exposure time.
Fund:The Key Projects of Zhejiang Medical and Health (2016ZDB011);Hangzhou Science and Technology Development Plan Project (20150733Q09)
Cite this article:
Wu Zhibing,Wu Kan,Wu Yajun et al. The effect of microwave radiation on the permeability change of blood brain barrier[J]. Chinese Journal of Radiation Oncology, 2018, 27(12): 1101-1105.
Wu Zhibing,Wu Kan,Wu Yajun et al. The effect of microwave radiation on the permeability change of blood brain barrier[J]. Chinese Journal of Radiation Oncology, 2018, 27(12): 1101-1105.
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