术后小细胞肺癌患者预防性脑照射研究进展

doi:10.3760/cma.j.issn.1004-4221.2018.11.018

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Abstract

The incidence of small cell lung cancer (SCLC) is relatively low, which approximately accounts for 13%-20% of all types of lung cancers. SCLC is characterized by high-degree malignancy and high metastasis and recurrence rates within a short period of time. Upon the confirmed diagnosis, limited-stage SCLC approximately accounted for 30% of SCLC and merely 5% of these patients were eligible for surgery. Over half of the patients who obtained complete remission after chemoradiotherapy presented with brain metastases. The postoperative incidence of brain metastases in patients with stage Ⅰ, Ⅱ and Ⅲ SCLC was 6%-14%,13%-38% and 11%-36%, respectively. Prophylactic cranial irradiation (PCI) can enhance the overall survival rate of patients with complete remission after chemoradiotherapy and reduce the incidence of brain metastasis, which is a pivotal part of comprehensive treatment of limited-stage SCLC. However, the application of PCI remains controversial in clinical practice and the clinical efficacy for patients with surgically resected SCLC significantly varies. In this article, literature review was conducted and the research progress in this field was summarized.

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	Articles by authors
	Chen Mengyuan
	Hu Xiao
	Wang Jin
	Chen Ming

Key words： Lung neoplasm/postoperative prophylactic cranial irradiation Prognosis Reasearch progress

Received: 10 May 2018

Corresponding Authors: Chen Ming,Email:chenming@zjcc.org.cn

Cite this article:

Chen Mengyuan,Hu Xiao,Wang Jin et al. Research progress on prophylactic cranial irradiation in patients with surgically resected small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2018, 27(11): 1026-1029.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.11.018 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I11/1026

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