食管癌放疗中左心室肌剂量体积指标评估误差研究

doi:10.3760/cma.j.issn.1004-4221.2018.09.009

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Abstract

Objective To evaluate the dynamic variation of the dose-volume parameters of the left ventricular myocardium following heart beat in radiotherapy for esophageal cancer. Methods The left ventricular myocardium of 22 patients was contoured on 20 phases (0%-95%) of electrocardiography (ECG) gated heart 4DCT images. The radiotherapy plan was designed on the simulation CT images,and then the dose distribution of radiotherapy plan was imported into MIM Maestro system and 4D dose-volume histogram (DVH) was reconstructed. The variations of position,volume and dice similarity coefficient (DSC) of the left ventricular myocardium were analyzed. The changing ranges of Dmean,V₁₀,V₂₀,V₃₀ and V₄₀ of the left ventricular myocardium during different phases were statistically compared. Results (1) The biggest displacement of the left ventricular myocardium was in Y axes. The maximum variation rate of volume and DSC of the left ventricular myocardium were (24.23±11.35)% and (184.33±128.61)% in different phases with statistical significance (both P<0.05).(2) The maximum variation rate of Dmean of the left ventricular myocardium was (87.05±38.34)% in different phases with the highest rate of 163.52% with statistical significance (P<0.05).(3) The maximum variation values of V₁₀,V₂₀,V₃₀ and V40 of the left ventricular myocardium were (13.64±4.33)%,(12.84±4.55)%,(11.62±4.85)% and (3.63±2.56)% with statistical significance (all P<0.05). Conclusions The impact of heart beat on the dose-volume parameters of the left ventricular myocardium should be considered during esophageal cancer radiotherapy. Traditional static 3DCT-based assessment of the dose-volume parameters of the left ventricular myocardium can yield relatively large errors,which is probably reduces the prediction efficiency of the dose-volume parameters for radiation-induced heart injury.

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	Articles by authors
	Tong Ying
	Yin Yong
	Lu Jie
	Chen Jinhu
	Liu Tonghai
	Cheng Pinjing
	Gong Guanzhong

Key words： Left ventricular myocardium Dose-volume parameter Variation

Received: 03 May 2017

Fund:

National Natural Science Foundation of China (81301936);Key Research& Development project in Shandong (2018GSF118048)

Corresponding Authors: Gong Guanzhong,Email:gongguanzhong@163.com

Cite this article:

Tong Ying,Yin Yong,Lu Jie et al. Analysis of the evaluation errors of dose-volume parameters for left ventricular myocardium in esophageal cancer radiotherapy[J]. Chinese Journal of Radiation Oncology, 2018, 27(9): 830-834.

URL:

http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.09.009 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I9/830

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