营养干预对食管癌同步放化疗疗效研究

doi:10.3760/cma.j.issn.1004-4221.2018.09.004

Abstract
Figure/Table
References()
Related Citation (15)
Read Tracking
Download Tracking

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS) Supporting Info

Abstract Objective To investigate the effect of nutritional intervention upon the clinical efficacy of chemoradiotherapy in patients diagnosed with esophageal carcinoma. Methods A total of 46 patients who were diagnosed with esophageal cancer in Anhui Cancer Hospital from November 2016 to August 2017 were enrolled in this prospective study. All patients were randomly and evenly divided into the nutritional intervention (NI) and routine treatment (RT) groups. The changes in body mass index (BMI),PG-SGA,serum albumin (ALB),hemoglobin (HB),white blood cell (WBC) and other Objective nutritional parameters and the incidence of chemoradiotherapy-induced complications were recorded before and after chemoradiotherapy. Results Prior to chemoradiotherapy,age,sex,BMI,ALB,PLT and clinical staging did not significantly differ between two groups (all P>0.05).In the NI group,the BMI was (21.52±2.67) after chemoradiotherapy,significantly higher than (21.13±2.73) before radiotherapy (P=0.000).Moreover,the PG-SGA score after chemoradiotherapy was significantly lower compared with that before chemoradiotherapy (P=0.000).In the RT group,the BMI,Hb,ALB,PLT and WBC after chemoradiotherapy were significantly lower than those before radiotherapy,and thePG-SGA score was worse after chemoradiotherapy (all P<0.05).In the NI group,the incidence of grade 3 myelosuppression was 4.34%,significantly lower than 8.68% in the RT group (P=0.000). Conclusions Patients with esophageal cancer treated with chemoradiotherapy have a high nutritional risk. Nutritional intervention can improve the nutritional status,reduce the incidence of chemoradiotherapy-induced complications,and probably improve the quality of life and clinical prognosis.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Yang Liping
	Gao Jin
	Zhou Yan
	Tao Zhenchao
	He Jian
	Yang Jing
	Wang Ru
	Zhang Yangyang
	Huang Yifan

Key words： Nutritional intervention Oral nutritional supplement Esophageal neoplasms radiotherapy Prognosis

Received: 16 October 2017

Corresponding Authors: Gao Jin,Email:gj11667@126.com

Cite this article:

Yang Liping,Gao Jin,Zhou Yan et al. Effect of nutritional intervention on clinical efficacy of chemoradiotherapy for esophageal carcinoma patients[J]. Chinese Journal of Radiation Oncology, 2018, 27(9): 809-813.

URL:

http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.09.004 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I9/809

[1] Bozzetti F,Mariani L,Lo Vullo S,et al. The nutritional risk in oncology:a study of 1,453 cancer outpatients[J].Support Care Cancer,2012,20(8):1919-1928.DOI:10.1007/ s00520-012-1387-x.
[2] Pan p,Tao G,Sun X.Subjective global assessment and prealbumin levels of esophageal cancer patients undergoing concurrent chemoradiotherapy[J].Nutr Hosp,2015,31(5):2167-2173.DOI:10.3305/ nh.2015.31.5.8596.
[3] Jemal A,Bray F,Center MM,et al. Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.DOI:10.3322/caac.20107.
[4] 廖君,解冬梅.食管癌术后放疗患者的营养状况和对放疗不良反应的影响[J].河北医药,2013,35(7):1017-1018.DOI:10.3969/J.issn.1002-7386.2013.07.027.
Liao J,Xie DM.Nutritional status and adverse effects of radiotherapy on postoperative radiotherapy of esophageal carcinoma [J].Hebei Med,2013,35(7):1017-1018.DOI:10.3969/J.issn.1002-7386.2013.07.027.
[5] Zhang L,Lu Y,Fang Y.Nutritional status and related factors of patients with advanced gastrointestinal cancer[J].BrJ Nutr,2014,111(7):1239-1244.DOI:10.1017/ s000711451300367 x.
[6] Bozzetti F,Forbes A.The ESPEN clinical practice Guidelines on Parenteral Nutrition:present status and perspectives for future research[J].Clin Nutr,2009,28(4):359-364.DOI:10.1016/j.cinu.2009.05.010.
[7] Hebuterne X,Lemaric E,Michallet M,et al. Prevalence of malnutrition and current use of nutrition support in patients with cancer[J].J Parenter Enteral Nutr,2014,38(2):196-204.DOI:10.1177/0148607113502674.
[8] Cacicedo J,Casquero F,Martine Z,et al. A prospective analysis of factor that influence weight loss in patients undergoing radiotherapy[J].Chin　J Cancer,2014,33(4):204-210.DOI:10.5732/cjc.013.10009.
[9] Bo Y,Wang K,Liu Y,et al. The Geriatric nutritional risk index predicts survival in elderly esophageal squamous cell carcinoma patients with radiotherapy[J/OL].PLoS One,2016,11(5):e115903.DOI:10.1371/joural.pone.0155903.
[10] Koom WS,Ahn SD,Song SY,et al. Nutritional status of patients treated with radiotherapy as determined by subjective global assessment[J].Radiat Oncol J,2012,　30(3):132-189.DOI:10.3857/roj.2012.30.3.132.
[11] Bollschweiler E,Herbold T,Plum P,et al. Pronostic relevance of nutritional status in patients with advanced esophageal cancer[J].Expert Rev Anti Ther,2013,13(3):275-278.DOI:10.1111/j.1442-2050.2012.01441.x.
[12] Kim JY,Wie GA,Cho YA,et al. Development and validation of a nutrition screening tool for hospitalized cancer patients[J].Clin Nutr,2011,30(6):724-729.DOI:10.1016/ J.cinu.2011.06.001.
[13] Jiang N,Zhao JZ,Chen XC,et al. Clinical determinants of weight Loss in patients with esophageal carcinoma during radiotherapy:Prospective longitudinal view[J].Asian Pac J Cancer Prev,2014,15(5):1943-1948.DOI:10.7314/APJCP.2014.15.5.1943.
[14] Fiore FD,Lecleire S,Pop D,et al. Baseline nutritional status is Predictive of response to treatment and survival in patients treated By definitive chemoradiotherapy for a locally advanced　Esophageal[J].Ann J Gastroenterol,2007,102(11):2557-2563.DOI:10.1111/j.1572-0241.2007.01437.x.
[15] Capuano G,Grosso A,Gentile PC,et al. Influence of weight loss　On outcomes in patients with head and neck cancer undergoing concomitant chemoradiotherapy[J].Head Neck,2008,30(4):503-508.DOI:10.1002/HED.20737.
[16] Suh YG,Lee U,Koom WS,et al. High-dose versus standard-dose radiotherapy with concurrent chemotherapy in stages Ⅱ-Ⅲ esophageal cancer[J].Jpn J Clin Oncol,2014,44(6):534-540.DOI:10.1093/jjco/hyu047.
[17] Allum WH,Griffin SM,Watson A,et al. Guidelines for the management of oesophageal and gastric cancer[J].Gut,2002,50 Suppl 5:v1-23.DOI:10.1136/gut.50.suppl 5.v1.
[18] Geisler JP,Linnemeier GC,Thomas AJ,et al. Nutritional assessment using prealbumin as an objective criterion to determine whom should not undergo primary radical cytoreductive surgery for ovairan cancer[J].Gynecol Oncol,2007,106(1):128-131.DOI:10.1016/j.jqyno.2007.03.008.
[19] Poulsen GM,Pedersen LL,Osterlind K,et al. Randomized trial of effects of individual nutritional counseling in cancer patients[J].Clin Nur,2014,33(5):749-753.DOI:10.1016/j.cinu.2013.10.019.
[20] 喻冰琪,王瑾,谢淑萍等.营养风险筛查工具NRS2002评估食管癌放疗患者营养状况的价值[J].中华放射肿瘤学杂志,2016,25(3):234-238.DOI:10.3760/cma.j.issn.1004-4221.2016.03.009.
Yu BQ,Wang J,Xie SP,et al.The value of nutritional risk screening tool NRS2002 in evaluation of nutritional status in patients with esophageal cancer after radiotherapy[J].Chin J Radiat Oncol,2016,25(3):234-238.DOI:10.3760/cma.j.issn.1004-4221.2016.03.009.