15例原发喉NK/T细胞淋巴瘤临床特征及预后分析

doi:10.3760/cma.j.issn.1004-4221.2018.06.012

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Abstract

Objective To analyze the clinical features and prognosis of extra-nodal nasal NK/T cell lymphoma originated from the larynx. Methods Clinical data of 15 cases of extra-nodal nasal NK/T-cell lymphoma originated from the larynx were retrospectively analyzed. The overall survival (OS) and progression-free survival (PFS) were calculated by Kaplan-Meier survival analysis. The effect of different clinical factors on the clinical prognosis was assessed by univariate analysis. Results Among 15 patients,13 cases were male and 2 female. The median age of onset was 40 years. In 8 cases,the lesions were confined to the larynx,and only 4 cases suffered from cervical lymph node involvement. According to Ann Abor staging,11 cases were classified as grade I,3 as grade Ⅱ and 1 as grade Ⅲ.The median OS was 28.0 months and the 5-year OS was 32.0%.The median PFS was 24.7 months and the 5-year PFS was 33.3%.Among 14 patients with stage Ⅰ/Ⅱ,the clinical prognosis of patients receiving combined chemo-radiotherapy was significantly better than those of their counterparts undergoing radiotherapy or chemotherapy alone (median OS:37.2 vs.11.2 vs.3.7 months,P=0.004). Conclusion Extra-nodal nasal NK/T cell lymphoma originated from the larynx is extremely rare,predominantly in middle-aged male patients. The general condition is relatively favorable. Patients present with multiple lesions in the early stage and relatively poor prognosis. The clinical efficacy of chemotherapy combined with radiotherapy is probably higher compared with that of radiotherapy or chemotherapy alone.

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	Articles by authors
	Tang Yu
	Zhang Ximei
	Wang Peiguo
	Hou Xiaorong
	Zhang Fuquan
	Zhang Yujing
	Zhu Yuan
	Cao Jianzhong
	Wu Junxin
	Wu Tao
	Zhu Suyu
	Qian Liting
	Qi Shunan
	Yang Yong
	Li Yexiong

Key words： Extra-nodal natural killer/T-cell lymphoma,nasal type Larynx Prognosis

Received: 27 March 2018

Fund:

National Major Research and Development Program (2016YFC0904600);Collaborative Innovation Fund of Chinese Academy of Medical Sciences (CIFMS)(2016-I2M-1-001,2017-I2M-3-005);National Natural Science Foundation of China Youth Program (81502659);Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2017PT32001)

Corresponding Authors: Li Yexiong,Email:yexiong12@163.com

About author:: Tang Yu and Zhang Ximei are the first authors who contributed to the article equally

Cite this article:

Tang Yu,Zhang Ximei,Wang Peiguo et al. Clinical features and prognosis analysis of 15 cases of extra-nodal nasal-type natural killer/T-cell lymphoma originated from the larynx[J]. Chinese Journal of Radiation Oncology, 2018, 27(6): 593-597.

URL:

http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.06.012 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I6/593

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