<sup>125</sup>I放射性粒子植入治疗乏氧肿瘤近期疗效的临床研究

doi:10.3760/cma.j.issn.1004-4221.2018.05.009

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Abstract Objective To study the short-term efficacy of computed tomography (CT)-guided iodine-125(¹²⁵I) radioactive seed implantation in the treatment of hypoxic tumors. Methods Twenty-two patients treated with ¹²⁵I radioactive seed implantation in our department from 2014 to 2016 were divided into hypovascular tumor group (hypoxic group,n=12) and hypervascular tumor group (non-hypoxic group,n=10) based on the hemodynamics of solid tumor evaluated by color Doppler ultrasound. The enhanced CT images were loaded to the three-dimensional particle implantation planning system for preoperative planning. After ¹²⁵I radioactive seed implantation,the D90 for target volume was verified to be 106-128 cGy. Treatment outcomes were evaluated according to the World Health Organization criteria at 1-3 months after surgery. Results In all the patients, the overall response rate was 82% at 3 months after surgery. There were no significant differences in response (complete response+ partial response) rates at 1, 2, or 3 months after surgery between the hypoxic group and the non-hypoxic group (P=0.840, 0.696, 0.840). Conclusions In the treatment of solid malignant tumor, ¹²⁵I radioactive seed implantation can overcome the resistance of hypoxic tumor to radiotherapy in vitro and achieve satisfactory short-term efficacy.

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Key words： Iodine-125 radioactive seed Hypoxic tumor Short-term efficacy

Received: 23 May 2017

Fund:Scientific Research Foundation of Dalian (2015E12SF150)

Corresponding Authors: Zhang Haichen,Email:zhc585@sohu.com

Cite this article:

. Short-term efficacy of iodine-125 radioactive seed implantation therapy for hypoxic tumors[J]. Chinese Journal of Radiation Oncology, 2018, 27(5): 478-482.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.05.009 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I5/478

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