基于重复增强4DCT探讨食管癌同步放化疗中心脏体积变化

doi:10.3760/cma.j.issn.1004-4221.2018.02.006

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Abstract Objective To detect the changes of heart volume during concurrent chemoradiotherapy for esophageal cancer based on repeated enhanced 4DCT. Methods Patients with squamous cell esophageal cancer underwent repeated enhanced 4DCT and 3DCT scans before and after 10,20 and 30 fractions of radiotherapy, respectively. The heart was contoured on 3DCT,end expiratory (EE) and maximum intensity projection (MIP) of 4DCTimages. The changes in theheart volume,blood pressure and heart rate were statistically compared at different time points. Results A total of forty-six patients completed 4 fractions of 3DCT and enhanced 4DCT scans. Compared with the initial values, the heart volume was significantly decreased by 3.27%,4.45% and 4.52% after 10 fractions of radiotherapy,and reduced by 6.05%,5.64% and 4.51% following 20 fractions of radiotherapy on 3DCT,EE and MIP,respectively (P=0.000-0.027).The heart volume after 30 fractions of radiotherapy did not significantly differ from the initial volume (P>0.05).After radiotherapy,there was a significant decrease inboth systolic and diastolic blood pressure (P=0.000 and P=0.009) and a significantincrease in the heart rate (P=0.001) compared with those measured before radiotherapy. ConclusionsEnhanced 4DCT scan can clearly reflect the changes of heart volume throughout concurrent chemoradiotherapy. The heart volume starts to shrink during the early stage of radiotherapy and continue to decrease until the middle-and late-stage, whereas it restores to the initial volume after radiotherapy. Simultaneously, blood pressure declines and heart rate is accelerated during radiotherapy.

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	Articles by authors
	Wang Xue
	Li Jianbin
	Wang Jinzhi
	Zhang Yingjie
	Li Fengxiang
	Wang Wei
	Guo Yanluan
	Shao Qian
	Xu Min
	Liu Xijun
	Wang Yue

Key words： Esophageal neoplasm/concurrent chemoradiotherapy Tomography,X-ray computed,four-dimensional Heart volume

Received: 31 July 2017

Fund:National Key Research and Development Project (2016YFC0904700),Shandong Province Key Research and Development Project (2016 GSF201093), Medical and Health Science and Technology Development Plan of Shandong Province (2015WSO160), Science and Technology Project of Shandong Academy of Medical Sciences (Youth Fund:2015-51)

Corresponding Authors: Li Jianbin,Email:lijianbin@msn.com

Cite this article:

Wang Xue,Li Jianbin,Wang Jinzhi et al. Application of repeated enhanced 4DCT to detect the changes of heart volume during concurrent chemoradiotherapy for esophageal cancer[J]. Chinese Journal of Radiation Oncology, 2018, 27(2): 150-154.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2018.02.006 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2018/V27/I2/150

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