FDG PET-CT显像代谢参数与食管癌放疗预后相关性研究

doi:10.3760/cma.j.issn.1004-4221.2017.12.008

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Abstract Objective To investigate the prognostic value of metabolic parameters of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET-CT) before radiotherapy in patients with esophageal cancer receiving radiotherapy. Methods We retrospectively analyzed the clinical data of 37 patients with stage Ⅱ-Ⅲ esophageal squamous cell carcinoma admitted to Anhui Provincial Hospital from 2010 to 2015, who underwent PET-CT scans within 4 weeks before radiotherapy. The following information was collected:age, sex, the location of primary lesion, clinical stage, and treatment regimen. The maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), metabolic tumor volume (MTV), PET tumor length (PTL), and total lesion glycolysis (TLG) were calculated. The optimal cut-off values of SUVmax, SUVmean, MTV, PTL, and TLG were determined by the receiver operating characteristic (ROC) curve. The Kaplan-Meier method was used to calculate survival rates, and the log-rank test was used for survival comparison and univariate prognostic analysis;the Cox model was used for multivariate prognostic analysis of significant variables. Results The area under the ROC curve suggested that MTV>TLG>PTL=0.713>0.679>0.670. The Kaplan-Meier survival analysis showed that patients had better survival time when MTV was less than 27.44 cm³, TLG was less than 166.2 g, and PTL was less than 36.74 mm (P<0.05). The Cox multivariate regression analysis showed that only MTV was an independent prognostic factor for radiotherapy in patients with esophageal cancer (P=0.000). Conclusions MTV, TLG and PTL have certain values in predicting the prognosis of patients with esophageal cancer before radiotherapy, and are helpful for selecting and adjust the clinical treatment regimen and improving the survival rate and prognosis.

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	Lin Hongxiao
	Qian Liting
	Pan Bo
	Yan Jianhua

Key words： Tomography,X-ray computed,Positron-emission Deoxyglucose Esophageal neoplasms/radiotherapy Prognosis

Received: 07 June 2017

Fund:Natural Science Foundation of Anhui Province (1508085SMH233)

Corresponding Authors: Qian Liting,Email:money2006@163.com

Cite this article:

Lin Hongxiao,Qian Liting,Pan Bo et al. Prognostic value of FDG PET-CT metabolic parameters before radiotherapy in patients with esophageal cancer receiving radiotherapy[J]. Chinese Journal of Radiation Oncology, 2017, 26(12): 1394-1398.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.12.008 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I12/1394

[1] Li HH,Zhang QZH,Xu L,et alClinical outcome of esophageal cancer after distal gastrectomy:a prospective study[J].Int J Surg,2008,6(2):129-135.DOI:10.1016/j.ijsu.2008.01.007.
[2] 中国非手术治疗食管癌临床分期专家小组.非手术治疗食管癌的临床分期标准(草案)[J].中华放射肿瘤学杂志,2010,19(3):179-180.DOI:10.3760/cma.j.issn.1004-4221.2010.03.001.Draft of clinical staging standard of patients with esophagealcarcinoma received non-surgical treatment[J].Chin J Radiat Oncol,2010,19(3):179-180.DOI:10.3760/cma.j.issn.1004-4221.2010.03.001.
[3] Vali FS,Nagda S,Hall W,et al. Comparison of standardized uptake value-based positron emission tomography and computed tomography target volumes in esophageal cancer patients undergoing radiotherapy[J].Int J Radiat Oncol Biol Phys,2010,78(4):1057-1063.DOI:10.1016/j.ijrobp.2009.09.022.
[4] Chen WQ,Zheng RS,Zhang SW,et al. The incidences and mortalities of major cancers in China,2010[J].Chin J Cancer,2014,33(8):402-405.DOI:10.5732/cjc.014.10084.
[5] van de Wiele C,Kruse V,Smeets P,et al. Predictive and prognostic value of metabolic tumour volume and total lesion glycolysis in solid tumours[J].Eur J Nucl Med Mol Imaging,2013,40(2):290-301.DOI:10.1007/s00259-012-2280-z.
[6] Omloo JMT,van Heijl M,Hoekstra OS,et al. FDG-PET parameters as prognostic factor in esophageal cancer patients:a review[J].Ann Surg Oncol,2011,18(12):3338-3352.DOI:10.1245/s10434-011-1732-1.
[7] Hatt M,Visvikis D,Albarghach NM,et al. Prognostic value of ¹⁸F-FDG PET image-based parameters in oesophageal cancer and impact of tumour delineation methodology[J].Eur J Nucl Med Mol Imaging,2011,38(7):1191-1202.DOI:10.1007/ s00259-011-1755-7.
[8] Jayachandran P,Pai RK,Quon A,et al. Postchemoradiotherapy positron emission tomography predicts pathologic response and survival in patients with esophageal cancer[J].Int J Radiat Oncol Biol Phys,2012,84(2):471-477.DOI:10.1016/j.ijrobp.2011.12.029.
[9] Li YM,Lin Q,Zhao L,et al. Pre-treatment metabolic tumor volume and total lesion glycolysis are useful prognostic factors for esophageal squamous cell cancer patients[J].Asian Pac J Cancer Prev,2014,15(3):1369-1373.DOI:10.7314/APJCP.2014.15.3.1369.
[10] Hong JH,Kim HH,Han EJ,et al. Total lesion glycolysis using FDG PET-CT as a prognostic factor for locally advanced esophageal cancer[J].J Korean Med Sci,2016,31(1):39-46.DOI:10.3346/jkms.2016.31.1.39.
[11] 陈龙奇.食管癌国际TNM分期第7版解读与评价[J].中华肿瘤杂志,2010,32(3):237-240.
Chen LQ.Understanding and appraisal of the new TNM classification for esophageal cancer in the AJCC Cancer Staging Manual (7th Ed)[J].Chin J Oncol,2010,32(3):237-240.
[12] Chan DSY,Fielding P,Roberts SA,et alPrognostic significance of 18-FDG PET-CT and EUS-defined tumour characteristics in patients with oesophageal cancer[J].Clin Radiol,2013,68(4):352-357.DOI:10.1016/j.crad.2012.08.012.
[13] 韩春,王澜,祝淑钗,等.非手术治疗食管癌临床分期标准对225例放疗患者的预后评价[J].中华放射肿瘤学杂志,2011,20(2):109-112.DOI:10.3760/cma.j.issn.1004-4221.2011.02.008.
Han C,Wang L,Zhu SC,et al. Evaluation of prognosis of clinical staging for esophageal carcinoma treated with non-surgical methods-addition with analysis of 225 patients[J].Chin J Radiat Oncol,2011,20(2):109-112.DOI:10.3760/cma.j.issn.1004-4221.2011.02.008.