分析FDG PET-CT与MRI影像组数在口咽鳞癌术后精确放疗的应用价值

doi:10.3760/cma.j.issn.1004-4221.2017.08.003

Abstract
Figure/Table
References()
Related Citation (7)
Read Tracking
Download Tracking

Download: PDF (1605 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS) Supporting Info

Abstract Objective To investigate the clinical values of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸FDG PET-CT) and magnetic resonance imaging (MRI) in precise radiotherapy after surgery in patients with oropharyngeal squamous cell carcinoma. Methods A total of 53 patients with oropharyngeal squamous cell carcinoma were enrolled and underwent PET-CT and MRI imaging within two weeks after surgery. The detection rates of residual lesions and lymph node metastases after surgery by PET-CT and MRI were compared on the basis of the pathological results of biopsy. The gross tumor volume (GTV) and clinical target volume (CTV) determined by PET-CT and MRI were compared;the normally distributed data were analyzed using the t test, and the skewed distribution data by the Wilcoxon rank sum test. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value in predicting precise radiotherapy after surgery, as determined by PET-CT and MRI, were compared with the chi-square test. Results Fourteen patients had residual lesions after surgery. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of PET-CT in detecting residual lesions after surgery were significantly higher than those of MRI (92.86%, 94.87%, 86.67%, 97.37%, and 94.34% vs. 57.14%, 76.92%, 47.06%, 83.34%, and 71.70%, all P<0.05);the specificity, positive predictive value, and accuracy of PET-CT in detecting lymph node metastases were also significantly higher than those of MRI (all P<0.05), except for the sensitivity and negative predictive value (P>0.05). For the 14 patients with residual lesions, GTV_PET/CT was significantly smaller than GTV_MRI(45.62±22.13 cm³ vs. 60.61±23.12 cm³, P=0.034), so did CTV (125.54±17.53 cm³ vs. 142.18±21.22 cm³, P=0.011). There was no significant difference between CTV_PET-CT and CTV_MRI in 39 patients without residual lesions after surgery (117.87±17.66 cm³ vs. 128.05±20.65, P=0.099). Conclusions PET-CT is superior to MRI in detecting the residual lesions and lymph node metastases after surgery in patients with oropharyngeal squamous cell carcinoma, which provides valuable information for radiotherapy planning.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Huang Rong
	Wu Hui
	Xu Jing
	Lu Xiaoxu
	Sun Xueming
	Wang Shujuan

Key words： Oropharyngeal neoplasms/radiotherapy Contrastive analysis Radiomics

Received: 18 January 2017

Corresponding Authors: :Wu Hui,Email:wuhui7008@126.com

Cite this article:

Huang Rong,Wu Hui,Xu Jing et al. Clinical values of ¹⁸FDG PET-CT and MRI in precise radiotherapy after surgery in patients with oropharyngeal squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2017, 26(8): 857-861.

URL:

http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.08.003 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I8/857

[1] Dissanayaka WL,Pitiyage G,Kumarasiri PV,et al. Clinical and histopathologic parameters in survival of oral squamous cell carcinoma[J].Oral Surg Oral Med Oral Pathol Oral Radiol,2012,113(4):518-525.DOI:10.1016/j.oooo.2011.11.001.
[2] Christof-Rsli MD,Tschudi DC,Gabriela-Studer MD,et al. Outcome of patients after treatment for a squamous cell carcinoma of the oropharynx[J].Laryngoscope,2009,119(3):534-540.DOI:10.1002/lary.20033.
[3] Bourhis J,Le-Maitre AB,Audry H,et al. Individual patients′ data meta-analyses in head and neck cancer[J].Cur Opin Oncol,2007,19(3):188-194.DOI:10.1097/CCO.0b013e3280f01010.
[4] Lyu K,Guo HM,Lu YJ,et al. Role of ¹⁸F-FDG PET-CT in detecting pelvic lymph-node metastases in patients with early-stage uterine cervical cancer:comparison with MRI findings[J].Nucl Med Commun,2014,35(12):1204-1211.DOI:10.1097/MNM.0000000000000198.
[5] Malik V,Harmon M,Johnston C,et al. Whole Body MRI in the Staging of Esophageal Cancer-A Prospective Comparison with Whole Body ¹⁸F-FDG PET-CT[J].Digest Surg,2015,32(5):397-408.DOI:10.1159/000431292.
[6] 徐国增,朱小东,李明耀.FDG PET或PET-CT与MRI判断鼻咽癌放疗后局部残留或复发价值荟萃分析[J].中华放射肿瘤学杂志,2010,19(5):391-395.DOI:10.3760/cma.j.issn.1004-4221.2010.05.002.
Xu GZ,Zhu XD,Li MY.Meta analysis of local residual or recurrence value of nasopharyngeal carcinoma after radiotherapy by FDG, PET or PET-CT and MRI[J].Chin J Radit Oncol,2010,19(5):391-395.DOI:10.3760/cma.j.issn.1004-4221.2010.05.002.
[7] Jin F,Zhu H,Fu Z,et al. Prognostic value of the standardized uptake value maximum change calculated by dual-time-point ¹⁸F-fluorodeoxyglucose positron emission tomography imaging in patients with advanced non-small-cell lung cancer[J].Oncotarg Ther,2016,9(5):2993-2999.DOI:10.2147/OTT.S104919.
[8] Sumi M,Ichikawa Y,Nakamura T.Diagnostic ability of apparent diffusion coefficients for lymphomas and carcinomas in the pharynx[J].Eur Radiol,2007,17(10):2631-1637.DOI:10.1007/s00330-007-0588-z.
[9] 朱超,姚远,马学真,等.PET-CT对非小细胞肺癌精确放疗靶区勾画的影响[J].国际肿瘤学杂志,2011,38(5):397-400.DOI:10.3760/cma.j.issn.1673-422X.2011.05.024.
Zhu C,Yao Y,Ma XZ,et al. Effect of PET-CT on delineation of target areas for accurate radiotherapy in non-small cell lung cancer[J].Int J Oncol,2011,38(5):397-400.DOI:10.3760/cma.j.issn.1673-422X.2011.05.024.
[10] 林勤,吴华,朱鹭超,等.FDG PET-CT与MRI在鼻咽癌原发灶靶区勾画中的对比研究[J].中华放射肿瘤学杂志,2012,21(6):492-495.DOI:10.3760/cma.j.issn.1004-4221.2012.06.003.
Lin Q,Wu H,Zhu LC,et al. Comparative study of. FDG, PET-CT and MRI in delineation of primary target regions of nasopharyngeal carcinoma[J].Chin J Radiat Oncol,2012,21(6):492-495.DOI:10.3760/cma.j.issn.1004-4221.2012.06.003.
[11] Daisne JF,Duprez T,Weynand B,et al. Tumor volume in pharyngolaryngeal squamous cell carcinoma:comparison at CT,MR imaging,and FDG PET and validation with surgical specimen[J].Radiology,2004,233(1):93-100.DOI:10.1148/radiol.2331030660.
[12] Faria SL,Menard S,Devic S,et al. Impact of FDG-PET-CT on radiotherapy volume delineation in non-small-cell lung cancer and correlation of imaging stage with pathologic findings[J].Int J Radiat Oncol Biol Phys,2008,70(4):1035-1038.DOI:10.1016/j.ijrobp.2007.07.2379.
[13] Gondi V,Bradley K,Mehta M,et al. Impact of hybrid fluorodeoxyglucose positron-emission tomography/computed tomography on radiotherapy planning in esophageal and non-small-cell lung cancer[J].Int J Radiat Oncol Biol Phys,2007,67(1):187-195.DOI:10.1016/j.ijrobp.2006.09.033.
[14] 朱苏雨,席许平,胡炳强.PET-CT用于肿瘤放疗计划靶区勾画的相关问题[J].中国肿瘤,2010,19(8):494-499.
Zhu SY,Xi XP,Hu BQ.PET-CT for tumor radiotherapy planning target delineation of related issues[J].Chin Tumor,2010,19(8):494-499.
15] Davis JB,Reiner B,Huser M,et al. Assessment of ¹⁸F PET signals for automatic target volume definition in radiotherapy treatment planning[J].Radiother Oncol,2006,80(1):43-50.DOI:10.1016/j.radonc.2006.07.006.
[16] Biehl KJ,Kong F,Dehdashti F,et al. FDG-PET definition of gross tumor volume for radiotherapy of non-small-cell lung cancer:is a single SUV threshold approach appropriate?[J].J Nucl Med,2006,47(11):1808-1812.