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Prognostic value of pretreatment serum hemoglobin level in early-stage extranodal nasal-type NK/T-cell lymphoma
Li Xue,Lan Shengmin,Cao Jianzhong,Zhang Ning,Yuan Qiang,Guo Ruyuan,Li Hongwei
Department of Medical Imaging,Shanxi Medical University,Taiyuan 030001,China (Li X,Zhang N,Yuan Q); Center of Radiation Oncology,The Affiliated Tumor Hospital of Shanxi Medical University,Shanxi Cancer Hospital,Taiyuan 030001,China (Lan SM,Cao JZ,Guo RY,Li HW)
Abstract Objective To investigate the effect of pretreatment serum hemoglobin (Hb) level on the prognosis of early-stage extranodal nasal-type NK/T-cell lymphoma. Methods A retrospective analysis was performed on the clinical data of 175 patients with stage Ⅰ or Ⅱ extranodal nasal-type NK/T-cell lymphoma who were admitted to The Tumor Hospital Affiliated to Shanxi Medical University from 2000 to 2015. The inclusion criteria included Ann Arbor Ⅰ/Ⅱ stage, the primary tumor located in the upper aerodigestive tract, without other malignant diseases, and complete clinical information and follow-up data. Of the 175 patients, 67 received chemotherapy alone, 8 received radiotherapy alone,100 received radiotherapy and chemotherapyed. The survival rate was calculated using the Kaplan-Meier method. The log-rank test was used for univariate prognostic analysis. The Cox regression model was used for multivariate prognostic analysis. Results The univariate analysis showed that pretreatment serum Hb level (≥120 g/L), lactate dehydrogenase (LDH) level (normal), Eastern Cooperative Oncology Group (ECOG) score (0-1), Ann Arbor stage (IE), and radiotherapy were associated with significantly improved progression-free survival (PFS) and overall survival (OS)(P=0.000-0.046). The multivariate analysis showed that pretreatment serum Hb level, LDH level, ECOG score, and Ann Arbor stage were independent prognostic factors for PFS and OS (P=0.000-0.040). Conclusion Patients with a high pretreatment serum Hb level (≥120 g/L) have a better prognosis than those with a low pretreatment serum Hb level (<120 g/L).
Fund:Research Project of Health and Family Planning Commission of Shanxi Province (2015051)
Corresponding Authors:
Cao Jianzhong,Email:caolv2000@163.com
Cite this article:
Li Xue,Lan Shengmin,Cao Jianzhong et al. Prognostic value of pretreatment serum hemoglobin level in early-stage extranodal nasal-type NK/T-cell lymphoma[J]. Chinese Journal of Radiation Oncology, 2017, 26(8): 899-903.
Li Xue,Lan Shengmin,Cao Jianzhong et al. Prognostic value of pretreatment serum hemoglobin level in early-stage extranodal nasal-type NK/T-cell lymphoma[J]. Chinese Journal of Radiation Oncology, 2017, 26(8): 899-903.
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2017, Vol. 26 
