胶质母细胞瘤室管膜下区(SVZ)放疗研究进展

doi:10.3760/cma.j.issn.1004-4221.2017.06.022

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Abstract Glioblastoma multiforme (GBM, WHO grade IV) contains some glioma stem cells which have unique self-renewal capacity and multilineage potency. There are numerous neural stem cells in the subventricular zone (SVZ) of adult human brain;it may also act as a storehouse of glioma stem cells that can promote the development and recurrence of a tumor. GBM involving SVZ is prone to early recurrence and intracranial metastasis after resection, so irradiation of the SVZ potentially influences the survival of GBM patients. This review provides a summary of related experimental and clinical studies, and discusses the value of irradiation of the SVZ in GBM patients and the direction of future research.

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	Articles by authors
	Wang Chengang
	Luo Yijun
	Li Minghuan
	Yu Jinming

Key words： Glioblastoma multiforme Subventricular zone Glioma stem cells Radiotherapy Prognosis

Received: 12 April 2016

Corresponding Authors: Li Minghuan,Email:sdlmh2014@163.com

Cite this article:

Wang Chengang,Luo Yijun,Li Minghuan et al. Research advances in subventricular zone irradiation in glioblastoma[J]. Chinese Journal of Radiation Oncology, 2017, 26(6): 702-705.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.06.022 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I6/702

[1] Ostrom QT,Gittleman H,Farah P,et al. CBTRUS statistical report:primary brain and central nervous system tumors diagnosed in the United States in 2006-2010[J].Neuro Oncol,2013,15 Suppl 2:ii1-56.DOI:10.1093/neuonc/not151.
[2] Stupp R,Mason WP,van den Bent MJ,et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma[J].N Engl J Med,2005,352(10):987-96.DOI:10.1056/NEJMoa043330.
[3] Hanahan D,Weinberg RA.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-74.DOI:10.1016/j.cell.2011.02.013.
[4] Singh SK,Hawkins C,Clarke ID,et al. Identification of human brain tumour initiating cells[J].Nature,2004,432(7015):396-401.DOI:10.1038/nature03128.
[5] Chen J,Li Y,Yu TS,et al. A restricted cell population propagates glioblastoma growth after chemotherapy[J].Nature,2012,488(7412):522-6.DOI:10.1038/nature11287.
[6] Pallini R,Ricci-Vitiani L,Banna GL,et al. Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme[J].Clin Cancer Res,2008,14(24):8205-12.DOI:10.1158/1078-0432.CCR-08-0644.
[7] Wang J,Wakeman TP,Lathia JD,et al. Notch promotes radioresistance of glioma stem cells[J].Stem Cells,2010,28(1):17-28.DOI:10.1002/stem.261.
[8] Bao S,Wu Q,McLendon RE,et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response[J].Nature,2006,444(7120):756-60.DOI:10.1038/nature05236.
[9] Sibin MK,Lavanya CH,Bhat DI,et al. CD₁₃₃ and BMI1 expressions and its prognostic role in primary glioblastoma[J].J Genet,2015,94(4):689-696.
[10] Barani IJ,Benedict SH,Lin PS.Neural stem cells:implications for the conventional radiotherapy of central nervous system malignancies[J].Int J Radiat Oncol Biol Phys,2007,68(2):324-33.DOI:10.1016/j.ijrobp.2007.01.033.
[11] Calabrese C,Poppleton H,Kocak M,et al. A perivascular niche for brain tumor stem cells[J].Cancer Cell,2007,11(1):69-82.DOI:10.1016/j.ccr.2006.11.020.
[12] Guerrero-Cazares H,Gonzalez-Perez O,Soriano-Navarro M,et al. Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brain[J].J Comp Neurol,2011,519(6):1165-80.DOI:10.1002/cne.22566.
[13] Fomchenko EI,Holland EC.Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment[J].Neurosurg Clin N Am,2007,18(1):39-58.DOI:10.1016/j.nec.2006.10.006.
[14] Ayuso-Sacido A,Moliterno JA,Kratovac S,et al. Activated EGFR signaling increases proliferation,survival,and migration and blocks neuronal differentiation in post-natal neural stem cells[J].J Neurooncol,2010,97(3):323-337.DOI:10.1007/s11060-009-0035-x.
[15] Abel TW,Clark C,Bierie B,et al. GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma[J].Mol Cancer Res,2009,7(5):645-653.DOI:10.1158/1541-7786.MCR-08-0477.
[16] Capilla-Gonzalez V,Guerrero-Cazares H,Bonsu JM,et al. The subventricular zone is able to respond to a demyelinating lesion after localized radiation[J].Stem Cells,2014,32(1):59-69.DOI:10.1002/stem.1519.
[17] Achanta P,Capilla-Gonzalez V,Purger D,et al. Subventricular zone localized irradiation affects the generation of proliferating neural precursor cells and the migration of neuroblasts[J].Stem Cells,2012,30(11):2548-60.DOI:10.1002/stem.1214.
[18] Panagiotakos G,Alshamy G,Chan B,et al. Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain[J].PLoS One,2007,2(7):e588.DOI:10.1371/journal.pone.0000588.
[19] Kalm M,Fukuda A,Fukuda H,et al. Transient inflammation in neurogenic regions after irradiation of the developing brain[J].Radiat Res,2009,171(1):66-76.DOI:10.1667/RR1269.1.
[20] Liu JL,Tian DS,Li ZW,et al. Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo[J].Brain Res,2010,1316:101-11.DOI:10.1016/j.brainres.2009.12.055.
[21] Young GS,Macklin EA,Setayesh K,et al. Longitudinal MRI evidence for decreased survival among periventricular glioblastoma[J].J Neurooncol,2011,104(1):261-269.DOI:10.1007/s11060-010-0477-1.
[22] Ho J,Ondos J,Ning H,et al. Chemoirradiation for glioblastoma multiforme:the national cancer institute experience[J/OL].PLoS One,2013,8(8):e70745.DOI:10.1371/journal.pone.0070745.
[23] Jafri NF,Clarke JL,Weinberg V,et al. Relationship of glioblastoma multiforme to the subventricular zone is associated with survival[J].Neuro Oncol,2013,15(1):91-96.DOI:10.1093/neuonc/nos268.
[24] Adeberg S,Bostel T,Konig L,et al. A comparison of long-term survivors and short-term survivors with glioblastoma,subventricular zone involvement:a predictive factor for survival?[J].Radiat Oncol,2014,9:95.DOI:10.1186/1748-717X-9-95.
[25] Adeberg S,Konig L,Bostel T,et al. Glioblastoma recurrence patterns after radiation therapy with regard to the subventricular zone[J].Int J Radiat Oncol Biol Phys,2014,90(4):886-893.DOI:10.1016/j.ijrobp.2014.07.027.
[26] Brock SC,Bonsall J,Luskin MB.The neuronal progenitor cells of the forebrain subventricular zone:intrinsic properties in vitro and following transplantation[J].Methods,1998,16(3):268-281.DOI:10.1006/meth.1998.0684.
[27] Gibbs IC,Haas-Kogan D,Terezakis S,et al. The subventricular zone neural progenitor cell hypothesis in glioblastoma:epiphany,Trojan Horse,or Cheshire fact?[J].Int J Radiat Oncol Biol Phys,2013,86(4):606-608.DOI:10.1016/j.ijrobp.2013.03.002.
[28] Evers P,Lee PP,DeMarco J,et al. Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma[J].BMC Cancer,2010,10:384.DOI:10.1186/1471-2407-10-384.
[29] Slotman BJE,Eppinga W,de haan PF,et al. Is irradiation of potential cancer stem cell niches in the subventricular zones indicated in GBM?[J].Int J Radiat Oncol Biol Phys,2011,81(2):(abstract 1058).
[30] Chen L,Guerrero-Cazares H,Ye X,et al. Increased subventricular zone radiation dose correlates with survival in glioblastoma patients after gross total resection[J].Int J Radiat Oncol Biol Phys,2013,86(4):616-622.DOI:10.1016/j.ijrobp.2013.02.014.
[31] Gupta T,Nair V,Paul SN,et al. Can irradiation of potential cancer stem-cell niche in the subventricular zone influence survival in patients with newly diagnosed glioblastoma?[J].J Neurooncol,2012,109(1):195-203.DOI:10.1007/s11060-012-0887-3.
[32] Elicin O,Inac E,Uzel EK,et al. Relationship between survival and increased radiation dose to subventricular zone in glioblastoma is controversial[J].J Neurooncol,2014,118(2):413-419.DOI:10.1007/s11060-014-1424-3.
[33] Lee P,Eppinga W,Lagerwaard F,et al. Evaluation of high ipsilateral subventricular zone radiation therapy dose in glioblastoma:a pooled analysis[J].Int J Radiat Oncol Biol Phys,2013,86(4):609-615.DOI:10.1016/j.ijrobp.2013.01.009.
[34] Hegi ME,Liu L,Herman JG,et al. Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity[J].J Clin Oncol,2008,26(25):4189-499.DOI:10.1200/JCO.2007.11.5964.
[35] Molenaar RJ,Verbaan D,Lamba S,et al. The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone[J].Neuro Oncol,2014,16(9):1263-1273.DOI:10.1093/neuonc/nou005.