DIBH技术对纵隔淋巴瘤累及部位放疗靶区与OAR受量影响

doi:10.3760/cma.j.issn.1004-4221.2017.06.007

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Abstract Objective Objective To evaluate the effect of deep inspiration breath-hold technique (DIBH) on the dosimetry of target volume and organs at risk (OARs) in mediastinal lymphoma irradiation. Methods This was a prospectively study and five patients with stage Ⅰ and Ⅱ mediastinal lymphomas were included continuously. The absolute target volume, the absolute OAR doses, and the relative doses to volume were compared between DIBH and free-breathing (FB) scans, based on the principles of the affected site irradiation and the “butterfly” field. The differences were analyzed using paired t test. Results The median age of these five patients was 30 years. Compared with FB scan, DIBH scan led to significant decreases in the gross tumor volume (GTV)(Δ=29.4 cm³, P=0.006) and the planning target volume (PTV)(Δ=322 cm³, P=0.005) before chemotherapy, while no significant difference in clinical target volume (CTV) was found. Meanwhile, the lung volume of DIBH scan was significantly increased (mean Δ=1456 cm³, P=0.001), while the heart width of DIBH scan was significantly reduced (Δ=1.3 cm, P=0.012), as compared with those of FB scan. The mean doses to the lung and heart were significantly lower in DIBH scan than in FB scan (heart:8.5±4.7 Gy vs. 11.6±4.7 Gy, P=0.022;lung:7.6±1.1 Gy vs. 11.6±1.4 Gy, P=0.000). The absolute target volume of the heart was significantly reduced at V₁₅ and above in DIBH scan than in FB scan (all P<0.05). Relative doses to volume of the lung and heart were significantly reduced at each dose level (from V₅ to V₃₅) in DIBH scan than in FB scan (all P<0.05). Conclusions DIBH technique can significantly reduce PTV, enlarge lung volume, and reduce the mean dose and relative doses to volume of the lung and heart at each level (from V₅ to V₃₅) compared with FB scan in mediastinal lymphoma radiation.

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	Articles by authors
	Qi Shunan
	Liu Zhiqiang
	Cao Ying
	Liu Shoufu
	Fang Hui
	Ren Hua
	Chen Bo
	Tang Yu
	Lu Ningning
	Li Ning
	Tang Yuan
	Song Yongwen
	Liu Yueping
	Wang Shulian
	Jin Jing
	Li Yexiong

Key words： Deep inspiration breath hold technique Mediastinal lymphoma Involved site radiotherapy Dose

Received: 09 February 2017

Corresponding Authors: Li Yexiong,Eamil:yexiong12@163.com

Cite this article:

Qi Shunan,Liu Zhiqiang,Cao Ying et al. Effect of deep inspiration breath-hold technique on dosimetry of target volume and organs at risk in mediastinal lymphoma irradiation[J]. Chinese Journal of Radiation Oncology, 2017, 26(6): 641-645.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.06.007 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I6/641

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