中高危局限期前列腺癌大分割及常规分割放疗疗效对比——<i>Meta分析</i>

doi:10.3760/cma.j.issn.1004-4221.2017.05.013

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Abstract Objective To compare the efficacy and adverse effects of hypofractionated radiotherapy versus conventionally fractionated radiotherapy for intermediate-to high-risk localized prostate cancer .Methods A literature search was performed in PubMed, Embase, Web of Science, CNKI, VIP database, and Wanfang Data to collect the controlled clinical trials of hypofractionated radiotherapy versus conventionally fractionated radiotherapy in patients with intermediate-to high-risk localized PCa published up to August 31, 2016. Stata 12.0 was used for meta-analysis. The difference between two groups was estimatedby calculating the hazard ratio (HR) or risk ratio (RR) with 95% confidence interval (CI). Results According to the inclusion and exclusion criteria, a total of 5 controlled clinical trials involving 1621 patients with PCa were included in this meta-analysis. The meta-analysis showed that overall survival (HR=1.00, 95%CI:0.85-1.17, P=0.980) and biochemical failure (RR=0.87, 95%CI:0.68-1.12, P=0.274) were comparable between the two groups. Compared with the conventionally fractionated radiotherapy, the incidence of acute gastrointestinal adverse events (grade≥2) was significantly higher in the hypofractionated radiotherapy (RR=1.94, 95%CI:1.23-3.06, P=0.004). However, there were no significant differences in the incidence of acute genitourinary adverse events (grade≥2)(RR=1.03, 95%CI:0.92-1.14,P=0.626), late gastrointestinal adverse events (grade≥2)(RR=1.17,95%CI:0.90-1.51, P=0.238), and late genitourinary adverse events (grade≥2)(RR=1.11, 95%CI:0.94-1.30, P=0.228) between the two groups. Conclusions Conventionally fractionated radiotherapy and hypofractionated radiotherapy have comparable therapeutic effects in patients with intermediate-to high-risk localized PCa. Although the patients treated with hypofractionated radiotherapy have a higher incidence of acute gastrointestinal adverse events than those treated with conventionally fractionated radiotherapy, the incidence of late gastrointestinal and genitourinary adverse events is comparable between the two groups of patients and the adverse effects are tolerable.

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	Guo Wei
	Gu Xiaobin
	Qi Xin
	Gao Xianshu
	Ma Mingwei
	Cui Ming
	Xie Mu
	Bai Yun
	Peng Chuan

Key words： Prostate neoplasms/radiotherapy Radiotherapy, hypofractionated Radiotherapy,conventional Meta-analysis

Received: 10 February 2017

Corresponding Authors: Gao Xiashu,Email:13911208977@139.com

Cite this article:

Guo Wei,Gu Xiaobin,Qi Xin et al. Efficacy and adverse effects of hypofractionated radiotherapy versus conventionally fractionated radiotherapy in patients with intermediate-to high-risk localized prostate cancer:a meta-analysis[J]. Chinese Journal of Radiation Oncology, 2017, 26(5): 542-545.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2017.05.013 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2017/V26/I5/542

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