AbstractObjective To investigate the factors associated with radiation-induced lung injury (RILI) caused by radiation therapy for lung cancer patients in Tibetan Plateau, China. Methods A total of 262 patients with non-small cell lung cancer (NSCLC) confirmed by pathology or cytology from April 2012 to February 2016, consisting of 138 native Tibetans living at an elevation over 3000 meters and 124 non-native Tibetans or non-Tibetan people, were analysed. All patients received intensity-modulated radiotherapy±chemotherapy and underwent CT follow-up for over 6 months. For patients with grade ≥2 RILI, the associations of ethnicity, age, sex, Karnofsky Performance Scale (KPS) score, clinical stage, chemotherapy, and smoking history with RILI were analyzed. For two groups of patients, native Tibetan population and non-native Tibetan population, the associations of sex, smoking history, chemotherapy, and radiation dose with RILI were analyzed. Radiation dose-volume parameters were compared using the chi-square test or ’s's exact test, and their correlations were analyzed using the Person correlation test;a multivariate analysis was performed using the logistic regression model. Results For the 262 NSCLC patients, ethnicity (P=0.040), sex (P=0.001), KPS score (P=0.026), presence or absence of smoking history (P=0.014), minimum lethal dose (P=0.037), V5(P=0.000), and V20(P=0.025) were found to be associated with the development of RILI. Further analysis showed that only the smoking history (P=0.013) was significantly correlated with demographic composition. And there was no significant relationship between radiation dose for different groups and the incidence of RILI (all P=>0.05). Conclusions Native Tibetan patients with NSCLC are more susceptible to RILI.
Zhang Kuan,Cui Ying,Ma Shengchun et al. Sensitivity analysis for radiation-induced lung injury caused by radiotherapy for lung cancer patients in Tibetan Plateau, China [J]. Chinese Journal of Radiation Oncology, 2017, 26(4): 390-393.
Zhang Kuan,Cui Ying,Ma Shengchun et al. Sensitivity analysis for radiation-induced lung injury caused by radiotherapy for lung cancer patients in Tibetan Plateau, China [J]. Chinese Journal of Radiation Oncology, 2017, 26(4): 390-393.
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